Table 2:
Adverse Cutaneous Reactions and Common Culprit Drugs

Reaction

Drugs

Exanthems Beta-lactam antibiotics, sulfonamides, erythromycin, gentamicin, anticonvulsants, gold salts
Urticaria, angioedema Antibiotics, radiographic contrast media, anesthetics, angiotensin-converting enzyme (ACE) inhibitors, nonsteroidal anti-inflammatory drugs, opiates, curare
Vasculitis Allopurinol, cimetidine, furosemide, penicillins, sulfonamides, hydantoin, thiazide diuretics
Fixed drug eruption Penicillins, tetracycline, sulfonamides, barbiturates, phenolphthalein, gold salts
Erythema multiforme,
Stevens-Johnson syndrome, toxic epidermal necrolysis
Sulfonamides, aromatic anticonvulsants (phenobarbital,
phenytoin, carbamazepine), penicillins, quinolone,
cephalosporins, nonsteroidal anti-inflammatory drugs, allopurinol
Anticoagulant skin necrosis Warfarin, heparin
Systemic lupus erythematosus Hydralazine, procainamide, isoniazid, chlorpromazine, penicillamine, phenytoin, sulfasalazine
Contact dermatitis Neomycin, benzocaine, paraben, ethylenediamine, formaldehyde, p-aminobenzoic acid (PABA), topical antihistamines, topical corticosteroids
Photodermatitis Coal tar derivatives, psoralen, chlorpromazine, tetracycline, doxycycline, promethazine, PABA, nonsteroidal
anti-inflammatory agents, sulfonamides, griseofulvin, psoralen
Pigmentary changes Oral contraceptives, phenothiazines, heavy metals, antimalarials, clofazimine, tetracycline, minocycline, amiodarone
  
Copyright 2002 The Cleveland Clinic Foundation

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