| Table 1: | ||||
|
Chemical
Mediators of Itch
|
||||
|
Amines
|
Proteases
and Kinins |
Prostaglandins
|
Neuropeptides
|
Opioids
|
| Histamine | Trypsin | Substance P | Met-enkephalin | |
| Serotonin | Chymase | Substance K | Leu-enkephalin | |
| Kallikrein | Endothelin | Morphine | ||
| Papain | Vasoactive
intestinal peptide (VIP) |
|||
| Bradykinin | Neurotensin | |||
| Calcitonin gene related peptide (CGRP) | ||||
| Adapted from Lerner EA. Chemical mediators of itching. In: Bernhard JD, ed. Itch: Mechanisms and Management of Pruritis. New York: McGraw-Hill, 1994:23. | ||||
|
Copyright
2002 The Cleveland Clinic Foundation
|