Table 1:
Causes of Hypocalcemia
Decreased Entry of
Calcium into the Circulation
Increased Loss of
Calcium from the Circulation
Other Causes
  • Hypoparathyroidism
    (absence of PTH secretion)
    • Postoperative
    • Autoimmune
      (isolated or part of polygandular autoimmune syndrome)
    • Congenital
      (mutations of CaSR, PTH, and parathyroid aplasia)
    • Pseudohypoparathyroidism, types 1a and 1b, and type 2
  • Magnesium depletion
  • Severe hypermagnesemia
  • Deficiency of vitamin D
  • Hyperphosphatemia
    • Renal failure
    • Rhabdomyolysis
    • Tumor lysis
    • Phosphate administration
  • Acute pancreatitis
  • Hungry bone syndrome
  • Chelation
    • Citrate
    • EDTA
    • Lactate
    • Foscarnet
  • Widespread osteoblastic metastases
    • Prostate cancer
    • Breast cancer
  • Sepsis
  • Fluoride administration
  • Surgery
  • Chemotherapy
    • Cisplatin
    • 5-fluorouracil
    • Leucovorin

 

CaSR = calcium-sensing receptor; PTH = parathyroid hormone; EDTA = ethylenediaminetetraacetic acid
Copyright 2004 The Cleveland Clinic Foundation

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