1. Hereditary hemochromatosis
    Type 1. HFE-related
       C282Y homozygotes
       C282Y:H63D compound heterozygotes
       Rare alternative HFE mutations
    Types 2,3, and 4 non-HFE mutations

2. Secondary iron overload
    Iron loading anemias with or without blood transfusion
    Chronic liver diseases
       Hepatitis B and C
       Alcoholic liver disease
       Nonalcoholic fatty liver disease
       Porphyria cutanea tarda
    Dietary iron overload
    Miscellaneous causes
       African iron overload with or without genetic predisposition
       Neonatal iron overload
       Aceruloplasminemia
       Atransferrinemia