Table 4: Common Causes of Isolated Bilirubin Elevation

Table 4:
Common Causes of Isolated Bilirubin Elevation
	Direct-reacting Bilirubin	Indirect-reacting Bilirubin	Associated Features
Liver disease, many types	Elevated	Elevated or normal	Liver enzymes often elevated
Hemolysis	Normal	Elevation represents more than 90% of total bilirubin	Anemia usual; increased reticulocyte count; normal liver enzymes (although LDH may be elevated)
Gilbert's Syndrome	Normal	Elevation represents (common) more than 90% of total bilirubin	No abnormal liver tests; no anemia. Onset late adolescence; fasting makes bilirubin rise