Table 10: Therapy of Prosthetic Valve Staphylococcal Endocarditis

Table 10:
Therapy of Prosthetic Valve Staphylococcal Endocarditis
Isolate	Antibiotic	Regimen	Duration (wk)
MSSA or MSSE	Oxacillin + gentamicin + rifampin	2 g IV every 4 h 1 mg/kg IV/IM every 8 h 300 mg PO every 8 h	>6 First 2 >6
MRSA or MRSE	Vancomycin + gentamicin + rifampin	1 g IV every 12 h 1 mg/kg IV/IM every 8 h 300 mg PO every 8 h	>6 First 2 >6
MRSA=methicillin-resistant Staphylococcus aureus; MRSE=methicillin-resistant Staphylococcus epidermidis; MSSA=methicillin-sensitive Staphylococcus aureus; MSSE=methicillin-sensitive Staphylococcus epidermidis; IV=intravenous; IM=intramuscular; PO=orally. Doses assume normal renal function. Adapted from reference 12