Table 9: Therapy of Native Valve Endocarditis for Penicillin-Insensitive Streptococci or Enterococci

Table 9:
Therapy of Native Valve Endocarditis for Penicillin-Insensitive Streptococci^a or Enterococci^b
Antibiotic	Regimen	Duration (wk)
Penicillin G + gentamicin	3 MU IV every 4 h 1 mg/kg IV/IM every 8 h	4-6^c 2-6^c
Vancomycin + gentamicin^d	1 g IV every 12 h 1 mg/kg IV/IM every 8 h	4-6^c 4-6
MU=million units; IV=intravenous; IM=intramuscular Does assume normal renal function. ^aMinimum inhibitory concentration=0.1-0.5 µg/mL. ^bMinimum inhibitory concentration >0.5 µg/mL. May want to clarify combo for entire course. ^cProlonged therapy for enterococci. ^dGentamicin with vancomycin only for enterococci. Adapted from reference 12