Table 1:
Peripheral Neuropathy Syndromes
I. Acute-Subacute Generalized Polyneuropathies
A. Sensorimotor

  

1. Acute motor and sensory axonal neuropathy syndrome
2. Alcohol/nutritional
3. Toxins (metals)
B. Motor > sensory
   1. Guillain-Barre syndrome
2. Acute motor axonal neuropathy syndrome
3. Porphyria
4. Diphtheria
5. Toxins (dapsone, vincristine)
C. Sensory
   1. Paraneoplastic/autoimmune (anti-Hu associated)
2. Vitamin B6 toxicity
3. Toxins (cisplatin)
4. Human immunodeficiency virus
II. Chronic Generalized Symmetric Polyneuropathies
A. Sensorimotor
   1. Diabetes
2. Uremia
3. Alcohol/nutritional
4. Dysproteinemias
5. Connective tissue diseases
B. Motor > sensory
   1. Chronic inflammatory demyelinating polyradiculoneuropathy
2. Dysproteinemias
3. Hypothyroidism
4. Toxins (amiodarone, cytosine arabinoside, metals, tacrolimus)
C. Sensory
  1. Paraneoplastic/autoimmune (anti-Hu associated)
2. Vitamin B6 toxicity
3. Sjögren's syndrome
4. Vitamin E deficiency
III. Inherited Generalized Symmetric Sensory and Motor Polyneuropathies
A. Charcot-Marie-Tooth disease types 1,2,3 and X
B. Familial amyloidosis
C. Hereditary predisposition to pressure palsies (focal and symmetric)
IV. Asymmetric Generalized Sensory and Motor Polyneuropathies
A. Vasculitis
B. Sarcoidosis
C. Diabetes
D. Lyme disease
V. Mononeuropathies
A. Compression and entrapment neuropatheis
B. Vasculitis
C. Diabetes
VI. Autonomic Neuropathies and Polyneuropathies with Prominent Autonomic Features
A. Acute
   1. Acute pandysautonomia (paraneoplastic and idiopathic)
2. Guillain-Barre syndrome
3. Botulism
4. Porphyria
5. Toxins (vincristine, amiodarone, cisplatin, organic solvents, metals)
B. Chronic
   1. Diabetes
2. Chronic pandysautonomia (paraneoplastic and idiopathic)
3. Amyloidosis
4. Riley-Day syndrome
 
Copyright 2004 The Cleveland Clinic Foundation

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