Table 3: Comparison of Newer Atypical Antipsychotics

Table 3:
Comparison of Newer Atypical Antipsychotics
Atypical Antipsychotic	Initial Dose(mg)	Standard Dose(mg/day)	Dosing Frequency	Max Dose	Advantages	Disadvantages
Clozapine	25-50	300-600	bid	900	Effective in refractory schizophrenia Lowest risk of extrapyramidal symptoms (EPS)	Agranulocytosis No liquid form No injectable form Weight gain, seizures
Olanzapine	5-10	15-20	qd to bid	20	Well tolerated Approved for acute mania	Weight gain No liquid form No injectable form
Quetiapine	25-50	400-600	bid	800	Well tolerated Lowest EPS risk	Slow titration Sedation No liquid form No injectable form
Risperidone	1-2	4-8	qd to bid	16	Well tolerated Well-defined dose range	Dose-dependent EPS No injectable form
Ziprasidone	40-80	80-160	bid	160	Well tolerated No weight gain Injectable form	qT prolongation Taken with food Nausea, insomnia No liquid form