Table 8:
Processes Associated with Alterations in DLCO
Decreases In DLCO
  • Obstructive lung diseases
    • Emphysema
    • Cystic fibrosis
  • Parenchymal lung diseases
    • Interstitial lung disease
      • Caused by fibrogenic dusts, eg, asbestois
      • Caused by biologic dusts, eg, allergic alveolitis
      • Drug reactions, eg, amiodarone, bleomycin
      • Idiopathic
    • Sarcoidosis
  • Pulmonary involvement in systemic diseases
    • Systemic lupus erythematosus
    • Progressive systemic sclerosis
    • Mixed connective tissue disease
    • Rheumatoid arthritis
    • Dermatomyositis-polymyositis
    • Wegener's granulomatosis
    • Inflammatory bowel disease
  • Cardiovascular diseases
  • Other
    • Diseases associated with anemia
    • Chronic renal failure
    • Chronic hemodialysis
    • Marijuana smoking
    • Acute and chronic ethanol ingestion
    • Freebasing cocaine
    • Ciagarette smoking
    • Bronchitis obliterans with organizing pneumonia (BOOP)
Increases In DLCO
  • Diseases associated with polycythemia
  • Pulmonary hemorrhage
  • Diseases associated with increased pulmonary blood flow such as left-to-right intracardiac shunts
  • Exercise
 
Copyright 2003 The Cleveland Clinic Foundation

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