| Table 2: | ||
|
First
Line Drugs Used In Chemotherapy of Tuberculosis: Dosages and Main Side
Effects
|
||
| Drug (Side Effects) |
Daily
Regimen |
Twice
or
Three Times Weekly |
| INH (Hepatitis, peripheral neuropathy, lupus-like syndrome, drug interactions) |
5
mg/kg
(max 300 mg) |
15
mg/kg |
| RIF (Drug interactions, orange discoloration of body fluids, GI upset, hepatitis, fever, hypersensitivity, acute renal failure, hemolytic anemia) |
10
mg/kg
(max 600 mg) |
10
mg/kg
(max 600 mg) |
| PZA (Hyperuricemia, gouty arthritis, rarely hepatitis) |
15-30
mg/kg
(max 2 g) |
50-70
mg/kg
(max 4 g) |
| ETB (optic neuritis, exfolliative rash) |
15-25
mg/kg
|
25-30
mg/kg
|
| SM (cochleo- and vestibulo-toxicity, nephrotoxicity) |
15
mg/kg
|
25-30
mg/kg
|
| AK
(Amikacin) (same as SM) |
7.5-10
mg/kg
|
|
|
Copyright
2004 The Cleveland Clinic Foundation
|
Return to Tuberculosis Chapter