| Table 1: | ||||
|
AJCC
2002 Revised Melanoma Staging
|
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|
Stage
|
Histological
Features/TNM Classification
|
Overall Survival |
||
|
1-year
|
5-year
|
10-year
|
||
|
0
|
Intraepithelial/in situ melanoma (TisN0M0) |
|
100% |
100% |
|
IA
|
< 1 mm without ulceration and Clark Level II/III (T1aN0M0) |
95%
|
88%
|
|
|
IB
|
<
1 mm with
ulceration or level IV/V (T1bN0M0) |
91%
|
83%
|
|
| 1.01-2 mm without ulceration (T2aN0M0) |
89%
|
79%
|
||
|
IIA
|
1.01-2 mm with ulceration (T2bN0M0) |
77%
|
64% |
|
|
2.01-4 mm without ulceration (T3aN0M0) |
79%
|
64% |
||
|
IIB
|
2.01-4 mm with ulceration (T3bN0M0) |
63%
|
51%
|
|
|
> 4 mm without ulceration (T4aN0M0) |
67%
|
54%
|
||
|
IIC
|
> 4 mm with ulceration (T4bN0M0) |
45%
|
32%
|
|
|
IIIA
|
Single regional nodal micrometastasis, nonulcerated primary (T1-4aN1aM0) |
69%
|
63%
|
|
| 2-3 microscopic regional nodes, nonulcerated primary (T1-4aN2aM0) |
63%
|
57%
|
||
|
IIIB
|
Single regional nodal micrometastasis, ulcerated primary (T1-4bN1aM0) |
53%
|
38%
|
|
| 2-3 microscopic regional nodes, ulcerated primary (T1-4bN2aM0) |
50% |
36%
|
||
|
Single regional nodal macrometastasis, nonulcerated primary (T1-4aN1bM0) |
59% |
48%
|
||
| 2-3 macroscopic regional nodes, nonulcerated primary (T1-4aN2bM0) |
46% |
39%
|
||
|
In-transit met(s)/satellite lesion(s) without metastatic lymph nodes (T1-4a/bN2cM0) |
30-50% |
|||
|
IIIC
|
Single microscopic regional node, ulcerated primary (T1-4bN1bM0) |
29%
|
24%
|
|
|
2-3 macroscopic regional nodes, ulcerated primary (T1-4bN2bM0) |
24%
|
15%
|
||
| 4 or more metastatic nodes, matted nodes/gross extracapsular extension, or in-transit met(s)/satellite(s) and metastatic nodes (anyTN3M0) |
27%
|
18%
|
||
|
IV
|
Distant skin, subcutaneous, or nodal mets with normal LDH (any TanyNM1a) |
59%
|
19%
|
16%
|
| Lung mets with normal LDH (anyTanyNM1b) |
57%
|
7%
|
3%
|
|
| All other visceral mets with normal LDH or any distant mets with increased LDH (anyTanyNM1c) |
41%
|
9%
|
6%
|
|
|
Below thickness is defined
as the thickness of the lesion using an ocular micrometer to measure the
total vertical height of the melanoma from the granular layer to the area
of deepest penetration. The Clark's level refers to levels of invasion according
to depth of penetration of the dermis. Adapted with permission from Balch et al. Final Version of the American Joint Committee on Cancer Staging System for Cutaneous Melanoma. J Clin Oncol 2001; 19:3635-3548. Lippincott Williams & Wilkins.© |
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Copyright
2002 The Cleveland Clinic Foundation
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