Table 1:
Cutaneous Manifestations of Diabetes Mellitus
Skin Disorder
Key Features
Diabetic dermopathy
(shin spots)
  • atrophic, hyperpigmented papules/plaques on the legs
  • very common finding
Diabetic thick skin
  • thickened skin on the hands (dorsum)
  • scleroderma-like changes of the hands with stiffening of the joints
  • scleredema-thickening of the skin on the upper back, posterior neck, and shoulders (uncommon)
Acanthosis nigricans
  • velvety plaques in interiginous areas (neck, axillae, groin)
  • common with obesity and diabetes
Yellow nails and skin
  • affects up to 50% of patients
Acquired perforating disorders
  • pruritic hyperkeratotic papules on the legs and trunk
  • histopathologically characterized by the transepidermal elimination of collagen and/or elastin
  • common in patients with diabetes and renal failure
Calciphylaxis
  • deep purpuric plaques with ulceration
  • affected patients often have diabetes and end stage renal disease with secondary hyperparathyroidism
  • poor prognosis
Necrobiosis lipoidica
diabeticorum
  • yellow-orange, atrophic plaques on the legs, especially the shins
  • majority of affected patients have diabetes
Diabetic bullae
  • spontaneous blistering of the hands and feet
  • heals without scarring
  
Copyright 2002 The Cleveland Clinic Foundation

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