Skin Signs of Systemic Disease -- Printable Tables

TITLE:	SKIN SIGNS OF SYSTEMIC DISEASE
AUTHORS:	SHARON J. LONGSHORE, MD -- Department of Dermatology
	KENNETH J. TOMECKI, MD -- Department of Dermatology
REVIEWED:	AUGUST 4, 2004

Table 1:
Cutaneous Manifestations of Diabetes Mellitus
Skin Disorder	Key Features
Diabetic dermopathy (shin spots)	atrophic, hyperpigmented papules/plaques on the legs very common finding
Diabetic thick skin	thickened skin on the hands (dorsum) scleroderma-like changes of the hands with stiffening of the joints scleredema-thickening of the skin on the upper back, posterior neck, and shoulders (uncommon)
Acanthosis nigricans	velvety plaques in interiginous areas (neck, axillae, groin) common with obesity and diabetes
Yellow nails and skin	affects up to 50% of patients
Acquired perforating disorders	pruritic hyperkeratotic papules on the legs and trunk histopathologically characterized by the transepidermal elimination of collagen and/or elastin common in patients with diabetes and renal failure
Calciphylaxis	deep purpuric plaques with ulceration affected patients often have diabetes and end stage renal disease with secondary hyperparathyroidism poor prognosis
Necrobiosis lipoidica diabeticorum	yellow-orange, atrophic plaques on the legs, especially the shins majority of affected patients have diabetes
Diabetic bullae	spontaneous blistering of the hands and feet heals without scarring

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