Table 4: Treatment of Wilson's Disease

Table 4:
Treatment of Wilson's Disease
Drug	Dose and Route of Administration
Penicillamine (Cupramine, Depen)	250 mg tid or qid p.o.
Trientine (Syprine)	250 mg tid or qid p.o.
Zinc salts sulfate, gluconate, or acetate	50 mg tid p.o. (as elemental zinc)
In all therapies, the goal is to reduce serum free copper (non-ceruloplasmin bound) to less than 10 µg/dL Zinc salts may be substituted as a maintenance therapy after adequate decoppering has been achieved, but may be the treatment of choice in selected asymptomatic Wilson's disease patients