Table 1: Diagnostic Criteria for Accelerated and Blast-Phase Chronic Myelogenous Leukemia

Table 1:
Diagnostic Criteria for Accelerated and Blast-Phase Chronic Myelogenous Leukemia
Accelerated Phase (Requires one or more of the following criteria):	Blast Phase (Requires one or more of the following criteria):
Blasts comprising 10 to 19% of the peripheral blood WBCs and/or of nucleated bone marrow cells >20% peripheral blood basophils Persistent thrombocytopenia (<100 x 10⁹/L) unrelated to treatment Persistent thrombocytosis (>1000 x 10⁹/L) unresponsive to treatment Increasing splenomegaly or leukocytosis unresponsive to treatment Cytogenetic evidence of clonal evolution	Blasts composing >20% of peripheral blood WBCs or of nucleated bone marrow cells Extramedullary blast proliferation Large foci or clusters of blasts in the bone marrow biopsy
Adapted with permission from IARC Press (Reference 1).