- Persistent
monocytosis (>1 x 109/L) in the peripheral blood
- No Philadelphia
chromosome or bcr/abl fusion gene
- <20% blasts
and promonocytes in the peripheral blood and bone marrow
- >1
myeloid lineage with dysplasia
- if there
is no dysplasia the diagnosis of CMML can still be made if
the other requirements are satisfied and:
- the marrow
cells contain an acquired, clonal cytogenetic abnormality,
or
- persistent
monocytosis for 3 months
and
- exclusion
of all other causes of monocytosis
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