| Table
3: |
|
Diagnostic
Criteria for Chronic Neutrophilic Leukemia
|
- Peripheral
blood leukocytosis >25 x 109/L
- Segmented
neutrophils and bands >80% of leukocytes
- Immature
granulocytes <10% of leukocytes
- Myeloblasts
<1% of leukocytes
- Hypercellular
bone marrow
- Increased
number and percentage of
neutrophilic granulocytes
- Nucleated
marrow cells with <5% myeloblasts
- Normal
neutrophilic maturation pattern
- Hepatosplenomegaly
- No Philadelphia
chromosome or bcr/abl fusion gene
- No other
cause for neutrophilia
- No infectious
or inflammatory process
- No evidence
of another myeloproliferative disease
- No evidence
of a myelodysplastic or myelodysplatic/myeloproliferative
disease
- No evidence
of a tumor or, if present, the myeloid cells must show clonality
|
| Adapted
with permission from IARC Press (Reference 1). |
|