Table 4. Recommended Dosing and Administration Guide for Oral Antiepileptic Agents

Drug	Initiating Dose	Titrating Schedule/Usual dose	Max Dose
Felbamate (divide dose TID or QID)	Adults: 1.2 gm/day Children: 15 mg/kg/day	Adults: Increase by 600 mg/day at 2W intervals to 2.4 g/day Children: Increase by 15 mg/kg/day at 1 W intervals	Adults: 3.6 gm/day Children: 45 mg/kg/day
Gabapentin	Adults: 300 mg HS x 1, then 300 mg TID Children: 5- 15 mg/kg/day	Adults: 900-2,400 mg/day divided TID Children: (3-12 years): 35-65 mg/kg/day divided TID	Adults: 4,800 mg/day Children: 90 mg/kg/day
Lamotrigine (Dose must be titrated over 8 to 12W to decrease incidence of rash)	Adults: 1) 50 mg QD x 2W¹, then 50 mg BID or 2W or 2) 25 mg QOD x 2W, followed by 25 mg QD x 2W² Children: 1) 0.6 mg/kg/day x 2W, then 1.2 mg/kg/day x 2W¹ or 2) 0.15 mg/kg/day (>6.7 to <14 kg, give 2 mg QOD) x 2W, then 0.3 mg/kg/day (>14 kg give 2 mg/day) x 2W², then 0.3 mg/kg/day	Adults: Increase by 100 mg/day every 1-2W effective dose range is 300-500 mg divided BID¹ Increase by 25-50 mg/day every 1-2W to maintenance dose of 200 mg QD² Children: Increase by 1.2 mg/kg/day every 1-2W, to an effective dose of 5-15 mg/kg/day QD or divided BID¹ Increase by 0.3 mg/kg/day every 1-2W to effective dose of 1-5 mg/kg/day QD or divided BID²	Adults: 700 mg QD¹ 200 mg QD² Children: 400mg/day¹ 200 mg/day²
Tiagabine	Adults: 4 mg QD x 1W Children (12 to 18 years): 4 mg QD x 1W	Adults: Increase by 4-8 mg at 1W intervals to a maintenance dose of 32-56 mg/day divided BID-QID Children: Increase to 8 mg daily in 2 divided doses for 1W; then increase by 4-8 mg weekly to response	Adults: 56 mg/day Children: 32 mg/day
Topiramate	Adults: 25-50 mg/day divided BID x 1W Children: 1-3 mg/kg/day	Adults: Increase daily dose by 25-50 mg at 1W intervals to a maintenance dose of 200-400 mg/day divided BID Children: 5-9 mg/kg/day divided BID	Adults: 800 mg/day Children: 9 mg/kg/day
Oxcarbazepine	Adults: 300 mg BID Children: 8-10 mg/kg/day divided BID	Adults: 1,200 mg/day as add-on therapy and 2,400 mg/day as monotherapy divided BID Children: Increase to maintenance dose over 2W; Maintenance dose dependent on weight	Adults: 2,400 mg/day Children: 600 mg/day
Levetiracetam	Adults: 1,000 mg/day divided BID	Adults: Increase by 1,000 mg/day every 2W	Adults: 3,000 mg/day
Zonisamide	Adults: 100 mg QD x 2W	Adults: Increase dose to 200 mg daily or divided BID x 2W and further inreases by 100 mg daily in 2W intervals	Adults: 800 mg/day

QID = Four times a day; TID = Three times a day; BID = Two times a day; QD = Once a day; QOD = Every other day; HS = At bedtime; W = Week(s) 1 = with hepatic enzyme-inducing AEDs (no VPA); 2 = with VPA
**Note: Must consider patient-specific factors (e.g., weight, concomitant medications, hepatic function, renal function) when dosing oral antiepileptic agents.

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