Table 3. Pharmacokinetic Parameters of Selected Azolesa
| Voriconazole (200 mg BID) |
Fluconazole (200 mg BID) |
Itraconazole |
Posaconazole
(200 mg BID) |
Ravuconazole (200 mg BID) |
|
|
Bioavailability
(%)
|
90
|
93
|
55b
|
N/A
|
N/A
|
|
Cmax
(mcg/mL)
|
2.7
— 6
|
5.6
— 9.6
|
1.1
— 2b
|
1.1
|
3.9
|
|
Tmax
(hr)
|
1
|
3
— 4
|
1
— 3
|
N/A
|
N/A
|
|
Volume
of Distribution (L)
|
2
L/kg
|
40
— 46
|
796
|
343
|
N/A
|
|
Protein
Binding (%)
|
51—
67
|
12
|
99
|
N/A
|
N/A
|
|
Half-life
(hr)
|
6
|
24
± 9
|
64
|
24
|
113
|
|
Primary
route of elimination
|
Hepatic
|
Renal
|
Hepatic
|
Hepatic
|
Hepatic
|
| aAdapted
from Ann Pharmacother 2000;34:1035 and Pharmacotherapy 2001;21:168S;b
Variability is a function of prandial state and oral formulation Q = every; BID = twice a day; hr = hrs |
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