Table 1. FDA-approved indications of the Proton Pump Inhibitors

Indication
Esomeprazole
(Nexium™)
Lansoprazole
(Prevacid®)
Omeprazole
(Prilosec™)
Pantoprazole
(Protonix®)
Rabeprazole
(Aciphex™)
Healing of erosive esophagitis
X
X
X
X
X
Maintenance of healed erosive esophagitis
X
X
X
X
X
Symptomatic gastroesophageal
reflux disease
X
X
X
X
  
Eradication of Heliobacter pylori infection
X
X
X
 
 
Prevention of NSAID-induced gastric ulcers
 
X
 
  
  
Treatment of NSAID-induced gastric ulcers
  
X
   
  
  
Healing of gastric ulcer
  
X
X
  
  
Healing of duodenal ulcer
  
X
X
  
X
Maintenance of duodenal ulcer
  
X
  
  
  
Treatment of pathological hypersecretory conditions
(eg, Zollinger-Ellison Syndrome)
  
X
X
  
X

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