Table 2. Comparison of the Pharmacokinetic Parameters of Various PPIs

Table 2. Comparison of the Pharmacokinetic Parameters of Various PPIs

Parameter	Esomeprazole	Lansoprazole	Omeprazole	Pantoprazole	Rabeprazole
Bioavailablitiy	90%	80%	30-40%	77%	52%
Acid liable	Yes	Yes	Yes	Yes	Yes
Enteric-coated formulation	Yes	Yes	Yes	Yes	Yes
Time to peak	1.5 hours	1.7 hours	0.5-3.5 hours	2.5 hours	2-5 hours
Half-life	1.2-1.5 hours	< 2 hours	0.5-1 hour	1-1.9 hours	1-2 hours
Excreted unchanged in the urine	< 1%	< 1%	0 %	0 %	0 %
Cytochrome P450 pathway*	CYP2C19, CYP3A4	CYP3A, CYP2C19	CYP2C9, CYP2C8, CYP2C18, CYP2C19, CYPA3/4, CYP3A1A2	CYP2C19, CYP3A4	CYP3A, CYP2C19
Protein binding	97%	97%	95%	98%	96.3%

* = predominate pathway is highlighted in bold