Table 3. Drug Interactions Reported in the Product Labeling of Various PPIs

Drug
Esomeprazole
Lansoprazole
Omeprazole
Pantoprazole
Rabeprazole
Drugs dependent on gastric pH for absorption*
X
X
X
X
X
Benzodiazepines
  
  
X
  
  
Cyclosporine
  
  
X
  
  
Diazepam
X
  
X
  
  
Digoxin
  
  
X
  
X
Disulfiram
  
  
X
  
  
Phenytoin
  
  
X
  
  
Theophylline
  
X
  
  
  
Warafin
  
  
X
  
  

* = decreased absorption of drugs requiring acidic pH for absorption (eg, ketoconazole, ampicillin, iron)

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