Table 3. Drug Interactions Reported in the Product Labeling of Various PPIs

Drug	Esomeprazole	Lansoprazole	Omeprazole	Pantoprazole	Rabeprazole
Drugs dependent on gastric pH for absorption*	X	X	X	X	X
Benzodiazepines			X
Cyclosporine			X
Diazepam	X		X
Digoxin			X		X
Disulfiram			X
Phenytoin			X
Theophylline		X
Warfarin			X

* = decreased absorption of drugs requiring acidic pH for absorption (eg, ketoconazole, ampicillin, iron)

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