Table 2. Dosage Parameters for Sildenafil, Vardenafil, and Tadalafil

Table 2. Dosage Parameters for Sildenafil, Vardenafil, and Tadalafil ^8-10
Parameter	Sildenafil	Vardenafil	Tadalafil
Initial Dose	50 mg	10 mg	10 mg
Dosing Range	25-100 mg	2.5-20 mg	5-20 mg
Maximum Dose	100 mg	20 mg	20 mg
Maximum Dosing Frequency	1 dose/day	1 dose/day	1 dose/day
Dose Adjustments	Age > 65 years, hepatic impairment: 25 mg Severe renal impairment (CrCl < 30 ml/min): 25 mg Concomitant medications: See full prescribing information	Age > 65 years: 5 mg Moderate hepatic impairment: initial 5 mg, max 10 mg Mild, moderate, severe renal impairment: No adjustment Concomitant medications: See full prescribing information	Age > 65 years: no dosage adjustment Mild or moderate hepatic impairment: max 10 mg once daily Severe hepatic impairment: not recommended Moderate renal impairment: initial 5 mg once daily, max 10 mg every 48 hours Severe renal impairment (CrCl < 30 ml/min) on hemodialysis: max 5 mg Concomitant medications: See full prescribing information





Onset	Take 60 minutes prior to sexual activity	Take 60 minutes prior to sexual activity	Take prior to anticipated sexual activity