Table 1: Naproxen Dosing for all Inpatient Celecoxib Orders
Indication
Celecoxib Order
Written For:

Convert to Following Naproxen Dose:

 

Osteoarthritis Symptoms

200 mg PO as a single dose

OR

100 mg PO twice daily

Naproxen 250 mg, 375 mg, or 500 mg PO twice daily

(May increase to 1500 mg/day) *
Rheumatoid Arthritis Symptoms

100 mg - 200 mg PO twice daily

Naproxen 250 mg, 375 mg, or 500 mg PO twice daily

(May increase to 1500 mg/day) *
Primary Dysmenorrhea

Day 1: 400 mg PO initially, followed by an additional 200 mg PO if needed.

 

Subsequent Days: 200 mg PO twice daily as needed

Naproxen 500 mg PO initially, followed by 250 mg every 6-8 hours as needed

(Maximum Daily Dose: 1250 mg) *
Acute Pain

Day 1: 400 mg PO initially, followed by an additional 200 mg PO if needed.

 

Subsequent Days: 200 mg PO twice daily as needed

Naproxen 500 mg PO initially, followed by 250 mg every 6-8 hours as needed

(Maximum Daily Dose: 1250 mg) *
Post-operative
Pain

Day 1: 400 mg PO initially, followed by an additional 200 mg PO if needed.

 

Subsequent Days: 200 mg PO twice daily as needed

Naproxen 500 mg PO initially, followed by 250 mg every 6-8 hours as needed

(Maximum Daily Dose: 1250 mg) *

Additional pain medications may be warranted.

* Patients at risk of developing NSAID-induced gastric ulcers (e.g., history of ulcers and symptoms, age >65 years, aspirin/anticoagulant use) should receive oral esomeprazole (Nexium ® ) 20 mg orally once daily (or an equivalent dose of the current preferred Formulary proton pump inhibitor) concomitantly with naproxen to prevent gastrointestinal bleeding.

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