Biologic Therapies IV

 

 

Biologic Therapies IV

Current and Emerging Indications

 

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The development of biologic agents has significantly improved the care of patients with autoimmune and inflammatory disorders. However, emerging patient care data, especially on side effects, have muddled the clinical practice picture.

The Cleveland Clinic R.J. Fasenmyer Center for Clinical Immunology has a highly successful record of providing evidence-based continuing medical education activities to practitioners in rheumatology. The Center's biannual Biologic Therapies Webcast Series have been key online resource for comprehensive reviews and clinical analyses of biologic therapies.

The Biologic Therapies Webcast Series IV: Current and Emerging Indications continues that successful tradition, both in terms of quality presentations and in fulfilling participants' educational objectives. An international faculty of experts who span a multitude of scientific disciplines will provide their insights on a variety of timely topics:

  • Research advances in immunodeficiencies and autoimmunity.
  • Approved biologic agents and clinical trial data.
  • Development of new biologic agents.
  • Toxicities associated with biologic agents.
  • Clinical implications and potential new indications
    • .

Webcasts
Nizar Zein, MD Biologics and the Liver - Is IL6 a Target of Concern?
Nizar Zein, MD

Estimated Time:  15 minutes
Release Date:  August 12, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date:  August 12, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Paul Emery, MD, MA, FRCP DEBATE:  Nonbiologic vs Biologic DMARDS
Paul Emery, MD, MA, FRCP
Larry Moreland, MD

Estimated Time: 1 hour
Release Date: August 9, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: August 9, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Chad Deal, MD Biologic Therapies for Metabolic Bone Disease - Risks and Benefits
Chad Deal, MD

Estimated Time: 30 minutes
Release Date: July 20, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: July 20, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Joanne L. Flynn, PhD Small Molecules - Science and Clinical Application?
Clifton O. Bingham III, MD

Estimated Time: 30 minutes
Release Date: July 18, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: July 18, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Joanne L. Flynn, PhD Lessons from Granulomatous Infections
Joanne L. Flynn, PhD

Estimated Time: 30 minutes
Release Date: July 13, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: July 13, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology

Scott Plevy, MD GI: New Targets and Therapies
Scott Plevy, MD

Estimated Time: 30 minutes
Release Date: July 5, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: July 5, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
R. John Looney, MD IVIG: Old Therapy, New Insights
R. John Looney, MD

Estimated Time: 30 minutes
Release Date: June 30, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 30, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
E. William St. Clair, MD Sjögren’s Syndrome and Biologic Therapies
E. William St. Clair, MD

Estimated Time: 30 minutes
Release Date: June 30, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 30, 2013
Specialties: Rheumatology, Immunology, Internal Medicine
Alan Tyndall, MD Advances in the Treatment of Scleroderma
Alan Tyndall, MD

Estimated Time: 15 minutes
Release Date: June 30, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 30, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology, Dermatology, Pulmonology, Orthopaedics
M. Elaine Husni, MD Cardiovascular Disease and Inflammation - Are Biologics Helpful or Harmful?
M. Elaine Husni, MD, MPH

Estimated Time: 30 minutes
Release Date: June 30, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 30, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Cardiology,

Carol Langford, MD Vasculitis – Current Practice and Biologics
Carol Langford, MD, MHS

Estimated Time: 30 minutes
Release Date: June 24, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 24, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Neurology
Christopher Ritchlin, MD, MPH Psoriatic Arthritis: Revisiting the GRAPPA Guidelines
Christopher Ritchlin, MD, MPH

Estimated Time: 30 minutes
Release Date: June 24, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 24, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Richard M. Ransohoff, MD PML and Biologics - State of the Art
Richard M. Ransohoff, MD

Estimated Time: 30 minutes
Release Date: June 24, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 24, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Christopher Ritchlin, MD, MPH Paradoxical Toxicity - Lessons from Psoriasis
Christopher Ritchlin, MD, MPH

Estimated Time: 30 minutes
Release Date: June 24, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 24, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Brian Mandell, MD, PhD Gout - Do Biologics Make Sense?
Brian Mandell, MD, PhD

Estimated Time: 30 minutes
Release Date: June 24, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 24, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Richard Furie, MD SLE and Biologic Therapies
Richard Furie, MD

Estimated Time: 30 minutes
Release Date: June 24, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 24, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Steve Gordon, MD Update on Screening for TB - Is Gamma IFN Release the Way to Go?
Steve Gordon, MD

Estimated Time: 30 minutes
Release Date: June 24, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 24, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Jonathan Kay, MD Biosimilars - Scientific and Regulatory Challenges
Jonathan Kay, MD

Estimated Time: 30 minutes
Release Date: June 24, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 24, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Jeffrey Cohen, MD Neurologic Diseases: New Targets and Therapies
Jeffrey Cohen, MD

Estimated Time: 45 minutes
Release Date: June 24, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 24, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Edward Keystone, MD, FRCPC TNF Failures: Sorting Out the Options
Edward Keystone, MD, FRCPC

Estimated Time: 30 minutes
Release Date: June 24, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 24, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Arthur Kavanaugh, MD IL6 Targeting
Arthur Kavanaugh, MD

Estimated Time: 30 minutes
Release Date: June 10, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 10, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Peter Taylor, MD RA: New Targets and Therapies
Peter Taylor, MD, PhD, MA

Estimated Time: 45 minutes
Release Date: June 10, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: June 10, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
E. William St. Clair, MD B Cell Targeting: Current and Future Options
E. William St. Clair, MD

Estimated Time: 30 minutes
Release Date: May 27, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: May 27, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Peter Taylor, MD T Cell Targeting: Current and Future Options
Peter Taylor, MD, PhD, MA

Estimated Time: 30 minutes
Release Date: May 27, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: May 27, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Alan Tyndall, MD The Evolution of Stem Cell Therapy for Autoimmune and Inflammatory Diseases
Alan Tyndall, MD

Estimated Time: 30 minutes
Release Date: May 27, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: May 27, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Leonard Calabrese, DO TNF Inhibitors: Mechanism of Action of the Class
Leonard Calabrese, DO

Estimated Time: 30 minutes
Release Date: May 27, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: May 27, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Paul Emery, MD Impact of Biologics on Rheumatic Diseases
Paul Emery, MD, MA, FRCP

Estimated Time: 30 minutes
Release Date: May 27, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: May 27, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology
Daniel Kastner, MD Biologic Basis of Autoinflammatory Diseases
Daniel Kastner, MD, PhD

Estimated Time: 45 minutes
Release Date: May 27, 2011
Type: Webcast

Technical Requirements: Flash Player
Expiration Date: May 27, 2013
Specialties: Rheumatology, Immunology, Internal Medicine, Gastroenterology

Series Objectives

  1. Review and describe recent advances in basic immunology including B cell biology, cytokine biology, biology of the inflammasome, cell trafficking, and interferon biology.
  2. Describe the molecular basis of intracellular signaling pathways (eg, JAK-STAT and other kinase pathways) as they relate to immune physiology in health and disease.
  3. Critically appraise data from preclinical models of disease and human immunodeficiency states as they apply to predicting efficacy and toxicity of current and future biologic therapies.
  4. Discuss clinical implications of data on stem cell therapy of autoimmune and inflammatory disease states.
  5. Describe the mechanisms of action, indications, and toxicity of newly approved biologic agents, including both monoclonal proteins and small molecules, intravenous immunoglobulins, and stem cell therapy, as well as those in late development, and assess their clinical implications for rheumatology, gastroenterology, dermatology, and neurology.
  6. Summarize recent data on side effects associated with biologic therapies (including infection, cardiovascular disease, and rare adverse events) and apply the data to patient care decisions.
  7. Review data from early and advanced clinical trials of approved and developing biologic therapies in a variety of inflammatory and autoimmune disorders including rheumatoid arthritis, lupus, psoriatic arthritis, spondylitis, inflammatory bowel disease, psoriasis, scleroderma, osteoporosis, Sjögren's syndrome, vasculitis, autoinflammatory diseases, and gout.
  8. Create management strategies for highly complex patient scenarios with biologics and compare those management decisions with global experts.

Target Audience

This series is directed to rheumatologists, gastroenterologists, dermatologists, internal medicine physicians, nurse practitioners, physician assistants, and other health care professionals interested in or using biologic therapies in autoimmune and inflammatory disorders.

Activity Director

Leonard Calabrese, DO
Professor of Medicine
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
Vice Chairman, Department of Rheumatic and Immunologic Diseases
R.J. Fasenmyer Chair of Clinical Immunology
Orthopaedic and Rheumatologic Institute
Cleveland Clinic
Cleveland, OH