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How to Obtain AMA PRA Category 1 Credit(s)™

  1. Read the CME lesson.
  2. Take the CME posttest.
  3. Login to your account.
  4. Complete the registration / evaluation form.
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Technical Requirements
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Target Audience

Researchers and clinicians (rheumatologists, gastroenterologists, dermatologists, and pulmonologists) involved with autoimmune and inflammatory disorders and, in particular, those with an interest in the field of TNF inhibitor therapy.

Activity Design

Each lesson within the Managing the Problem Patient with Anti-TNF Inhibitors: Infectious, Malignant, Neurologic and Other Complex Issues Series includes a problem case, summary & recommendations, summary article, post-test and an evaluation.


At the conclusion of this activity, the participant will be able to:

  1. Describe the role of tumor necrosis factor (TNF) in sarcoidosis.
  2. Summarize the clinical experience with TNF antagonists in sarcoidosis.
  3. Identify potential pitfalls in treatment of sarcoidosis patients with TNF antagonists.

Co-Activity Directors

Nizar N. Zein, MD
Director of Clinical Hepatology
Department of Gastroenterology & Hepatology
Digestive Disease Center
The Cleveland Clinic
Cleveland, Ohio

Leonard H. Calabrese, DO
Vice Chairman, Department of Rheumatic & Immunologic Diseases
R.J. Fasenmyer Chair in Clinical Immunology
The Cleveland Clinic
Cleveland, Ohio


Daniel A. Culver, DO, FCCP

Faculty Disclosure

In accordance with the Standards for Commercial Support issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Foundation Center for Continuing Education requires resolution of all faculty conflicts of interest to ensure CME activities are free of commercial bias.

The following faculty have indicated that they may have a relationship, which in the context of their presentation(s), could be perceived as a potential conflict of interest:

Leonard H. Calabrese, DO — Consulting, Teaching and Speaking: Abbott, Amgen-Wyeth

Daniel A. Culver, DO — Teaching and Speaking: Centocor

The following faculty has indicated he/she has no relationship which, in the context of their presentation(s), could be perceived as a potential conflict of interest:

Nizar N. Zein, MD

This CME activity was produced by The Cleveland Clinic Foundation
Center for Continuing Education and UNITECH Communications®.

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