Accreditation

Target Audience

Researchers and clinicians (rheumatologists, gastroenterologists, dermatologists, and pulmonologists) involved with autoimmune and inflammatory disorders and, in particular, those with an interest in the field of TNF inhibitor therapy.

Activity Design

Each lesson within the Managing the Problem Patient with Anti-TNF Inhibitors: Infectious, Malignant, Neurologic and Other Complex Issues Series includes a problem case, summary & recommendations, summary article, post-test and an evaluation.

Objectives

At the conclusion of this activity, the participant will be able to:

1. Review the differential diagnosis of neurological manifestations in patients with immune mediated inflammatory disorders taking TNF antagonists.
2. Summarize the animal and human studies that address the associated of demyelinating disorders with the use of anti-TNF agents.
3. Discuss the evaluation and treatment of patients on TNF antagonists who develop CNS adverse events.
4. view approaches to identifying and monitoring patients at increased risk for neurologic complications of TNF antagonists.

Co-Activity Director / Author

Nizar N. Zein, MD
Director of Clinical Hepatology
Department of Gastroenterology & Hepatology
Digestive Disease Center
The Cleveland Clinic
Cleveland, Ohio

Co-Activity Director

Leonard H. Calabrese, DO
Vice Chairman, Department of Rheumatic & Immunologic Diseases
R.J. Fasenmyer Chair in Clinical Immunology
The Cleveland Clinic
Cleveland, Ohio

Faculty Disclosure

In accordance with the Standards for Commercial Support issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Foundation Center for Continuing Education requires resolution of all faculty conflicts of interest to ensure CME activities are free of commercial bias.

The following faculty have indicated that they may have a relationship, which in the context of their presentation(s), could be perceived as a potential conflict of interest:

Leonard H. Calabrese, DO — Consulting, Teaching and Speaking: Abbott, Amgen-Wyeth

The following faculty has indicated he/she has no relationship which, in the context of their presentation(s), could be perceived as a potential conflict of interest:

Nizar N. Zein, MD