Biologic Therapies: Clinical
Implications for Rheumatologists,
Gastroenterologists, Allied Health
Practitioners
Release Date: January 26, 2010
Expiration Date: January 26, 2012
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How to Obtain AMA PRA
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Estimated Time of Completion: 45 minutes
Description
Biologic agents have become an important part of the therapeutic strategies for clinicians caring for patients with rheumatic and inflammatory diseases. These therapies, however, have varying efficacy and safety profiles depending on the specific disease. Understanding the potential role and risks of these biologics is important for clinicians to maximize outcomes from these therapies.
This manuscript presents a review of biologics in specific populations with diseases related to rheumatology and gastroenterology as well as presentations on how to effectively administer the agents.
Objectives
After completing this learning activity, the participant will be able to:
- Discuss the safety and efficacy of biologic agents that have been studied in Wegener’s granulomatosis, psoriatic arthritis, and systemic vasculitis.
- Discuss the risks and benefits of biologic therapy in patients with inflammatory bowel disease.
- Describe the potential for developing PML with natalizumab and the initial evaluation and therapy of this serious adverse effect.
- Summarize the rationale for biologic use in the treatment of nonalcoholic fatty liver disease.
- Create a management plan regarding dosing and safety issues associated with biologic therapies for rheumatoid arthritis.
Target Audience
Rheumatologists, gastroenterologists and other health care professionals managing patients with rheumatologic diseases.
Accreditation
The Cleveland Clinic Foundation Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The Cleveland Clinic Foundation Center for Continuing Education designates this educational activity for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association Council on Continuing Medical Education for Category 2 credit.
Activity Director
Leonard Calabrese, DO
Professor of Medicine
Cleveland Clinic Lerner College of Medicine of
Case Western Reserve University
Vice Chairman, Department of Rheumatic &
Immunologic Diseases
R.J. Fasenmyer Chair of Clinical Immunology
Orthopaedic & Rheumatologic Institute
Cleveland Clinic
Cleveland, OH
| Aaron Brzezinski, MD Department of Gastroenterology & Hepatology Digestive Disease Institute Cleveland Clinic Cleveland, OH |
Elizabeth Kirchner, CNP Department of Rheumatic & Immunologic Diseases Orthopaedic & Rheumatologic Institute Cleveland Clinic Cleveland, OH |
Arthur McCullough, MD Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Chairman, Department of Gastroenterology & Hepatology Digestive Disease Institute Cleveland Clinic Cleveland, OH |
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| Tiffany Clark, RN, MSN, CNP Department of Rheumatic & Immunologic Diseases Orthopaedic & Rheumatologic Institute Cleveland Clinic Cleveland, OH |
Carol Langford, MD, MHS Associate Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Director, Center for Vasculitis Care & Research Cleveland Clinic Cleveland, OH |
Christopher Ritchlin, MD Associate Professor of Medicine Allergy, Immunology & Rheumatology Unit University of Rochester Medical Center Rochester, NY |
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| Carmen Gota, MD Department of Rheumatic & Immunologic Diseases Orthopaedic & Rheumatologic Institute Cleveland Clinic Cleveland, OH |
Bret Lashner, MD Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Program Director Gastroenterology Fellowship Program Director, Center for Inflammatory Bowel Disease Department of Gastroenterology & Hepatology Digestive Disease Institute Cleveland Clinic Cleveland, OH |
Nizar Zein, MD Associate Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Chief, Section of Hepatobiliary Diseases Department of Gastroenterology & Hepatology Digestive Disease Institute Cleveland Clinic Cleveland, OH |
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| M. Elaine Husni, MD, MPH Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Director, Clinical Outcomes Research Director, Arthritis & Musculoskeletal Treatment Center Department of Rheumatic & Immunologic Diseases Orthopaedic & Rheumatologic Institute Cleveland Clinic Cleveland, OH |
Faculty Disclosure
In accordance with the Standards for Commercial Support issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Foundation Center for Continuing Education requires resolution of all faculty conflicts of interest to ensure CME activities are free of commercial bias.
The following faculty have indicated that they may have a relationship which, in the context of their presentation, could be perceived as a potential conflict of interest:
| Aaron Brzezinski, MD | ||
| Teaching and Speaking: | Centocor; Elan; UCB | |
| Leonard Calabrese, DO | ||
| Consulting: | Elan; Roche | |
| Consulting, Teaching and Speaking: | Abbott; Amgen; Centocor; Genentech; Wyeth | |
| Carol Langford, MD, MHS | ||
| Research: | Bristol Myers Squibb; Genentech | |
| Bret Lashner, MD | ||
| Consulting, Teaching and Speaking: | Abbott; Elan; UCB | |
| Christopher Ritchlin, MD | ||
| Consulting: | Abbott; Amgen; Wyeth | |
| Consulting and Research: | Centocor | |
The following faculty have indicated they have no relationship which, in the context of their presentation, could be perceived as a potential conflict of interest:
Tiffany Clark, RN, MSN, CNP
Carmen Gota, MD
M. Elaine Husni, MD, MPH
Elizabeth Kirchner, CNP
Arthur McCullough, MD
Nizar Zein, MD
The Cleveland Clinic Foundation Center for Continuing Education
acknowledges an educational grant for support of this activity from:
Abbott Laboratories
Amgen and Wyeth Pharmaceuticals
Centocor, Inc.
Genentech and Biogen Idec
Roche Laboratories, Inc.
UCB, Inc.
This CME activity was produced by The Cleveland Clinic Foundation
Center for Continuing Education
and the R.J. Fasenmyer Center for Clinical Immunology.
