Table 4: Pharmacotherapy for the Prevention and Treatment of Osteoporosis
Medication
Dosage
Side Effects/General Information
  Estrogen
  Estraderm®
  Vivelle®
  Climara®
  FemPatch®
  Premarin®
  
  Estradiol transdermal systems :
  •      Alora®, Estraderm®
, Vivelle® are
         applied twice a week
  •     Climara® and FemPatch® are applied
         every 7 days
  Congested estrogens 0.625 mg/day
  administered orally
  Used for prevention and treatment

  Drug choice in postmenopausal women.
  Must be taken with a progestin in women with an in-
  tact uterus to prevent endometrial cancer.
  Contraindicted in women with a high risk of breast
  cancer, deep vein thrombosis, or unexplained uterine
  bleeding.
  Alendronate (Fosamax®)   5 mg/day administered orally for prevention
  10 mg/day administered orally for treatment
  Associated with esophagitis and gastrointestinal dis-
  tress.

  Used when estrogen therapy is contraindicted or not
  tolerated.
  Raloxifene (Evista®)   60 mg/day administered orally without food
  Used for prevention
  May increase symptoms of menopause (e.g., hot
  flashes).
  May increase the risk of deep vein thrombosis.
  May be used in women who cannot take estrogens
  due to an increased risk of breast cancer.
  Calcitonin-salmon
  •    Calcimar® or Miacalcin®
       injection
  •    Miacalcin® nasal spray


•   100 IU SC or IM daily or every other
       day
•   One spray (200 IU) daily, alternating
      nostrils

  Used for prevention and treatment

  Used when estrogen therapy is contraindicted or not
  tolerated.