| Table 1: Dosing of Daptomycin for FDA-Approved Indications20 | |
|
Infection
|
Dose
|
| Complicated skin and skin structure infections | 4 mg/kg IV every 24 hours |
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| Table 2: Dosing of Daptomycin for Non-FDA-Approved Indications23 | |
|
Infection
|
Dose
|
| Bacteremia/endocarditis | 6 mg/kg IV every 24 hours |
| VRE infections | 6 mg/kg IV every 24 hours |
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| Table 3: Recommended Dose Adjustment in Renal Impairment20 | |
|
Creatinine
Clearance(CrCl)
|
Dose*
|
| >30 mL/min | 4-6 mg/kg IV every 24 hours |
| <30 mL/min, including HD and CAPD | 4-6 mg/kg IV every 48 hours |
*mg/kg dose based on indication
HD = Hemodialysis; CAPD = Continuous Ambulatory Peritoneal Dialysis
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| Table 4: Daily Cost of Therapy | ||
|
Drug
|
Dose
|
Drug
Cost/Day
|
| Daptomycin (CubicinTM) | 4 mg/kg IV every 24 hours (70 kg) |
$72
|
| 6 mg/kg IV every 24 hours (70 kg) |
$110
|
|
| Linezolid (Zyvox®) | 600 mg IV every 12 hours |
$130
|
| 600 mg orally every 12 hours |
$100
|
|
| Quinupristin/dafopristin (Synercid®) | 7.5 mg/kg IV every 8 hours (70 kg) |
$255
|
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