Table 2. Dosage Administration

	Donepezil	Galantamine	Rivastigmine	Tacrine
Initial Dose	5 mg QD	4 mg BID	1.5 mg BID	10 mg QID
Titration	Increase to 10 mg QD after 4 to 6 weeks	Titrate slowly over intervals of 4 weeks	Increase to 3 mg BID, 4.5 mg BID, then 6 mg BID daily at 2-week intervals as tolerated	Increase to 20 mg QID, then 30 mg QID, and 40 mg QID at 4-week intervals as tolerated (monitor transaminase levels)
Maximum Dose	10 mg QD	24 mg/day	6 mg BID (12 mg/day)	40 mg QID (160 mg/day)
Time of Administration	Bedtime	Morning and evening	Morning and evening	Ideally administered between meals QID
Food	With or without	Take with food	Take with food	Between meals if possible, can be taken with food to improve tolerability, but reduces plasma levels 30 to 40%
Product Formulations	Tablet	Tablet	Capsule	Capsule

QD = once daily; BID = twice daily; QID = four times daily