Table 2. Factor IX Products Available in the United States*
Product (Manufacturer)
Source
Viral Inactivation Procedure
Average Cost
Per Dose ($)a,b
High-purity (SA: >160 U/mg protein)
MonoNine® (Aventis Behring)
Human plasma
Sodium thiocyanate
8,260
AlphaNine-SD®
(Alpha Therapeutic)
Human plasma
Solvent and detergent
7,700
BeneFix® (Genetics Institute)
Recombinant
Immunoaffinity chromatography
8,820
a Cost based on average wholesale price and represents the drug cost to the pharmacy department; b Cost based on the dose required to acheive a FIX level 100% of normal for a 70-kg patient; Abbreviations: SA=specific activity; *Adapted from: Shord SS, Lindley CM. Coagulation products and their uses. Am J Health-Syst Pharm 2000;57:1403-20 and DiMichele D, Neufeld EJ. Hemophilia: A new approach to an old disease. Hematol Oncol Clin North Am 1998;12:1315-44.

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