Table 1. Characteristics of the Two Types of Heparin-Induced Thrombocytopenia

Characteristic Type I Type II
Frequency 10 to 20%
Timing of onset 2 to 3 days 5 to 10 days
Nadir platelet count 100,000/µl 10,000 to 20,000/µl
Antibody mediated No Yes
Thromboembolic sequelae None 30 to 80%
Treatment Observe Patient Discontinue heparin by all routes, select other anticoagulation, adjunctive therapy


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