CONTACT INFORMATION
Center for Continuing Education
800.238.6750
or 216.448.0770
Online Registration Assistance
216.448.0777
cmeregistration@ccf.org |
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Description
Health care practitioners and researchers need to stay abreast of recent
developments on fibrosis, a common and serious complication of chronic
inflammation, and their effects on clinical practice. Recognizing this need,
the Cleveland Clinic is bringing together leaders in gastroenterology to
discuss the most effective clinical practices related to fibrotic complications
in gastrointestinal diseases. These experts will compile and critically appraise
new evidence and interpret their applications to clinical practice.
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Target Audience
Academic gastroenterologists, surgeons, basic scientists, and other
health care professionals interested in mechanisms of fibrogenesis of the
gastrointestinal tract and liver and new emerging therapeutic options.
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Objectives
After completing this activity, the participant will be able to do the following:
- Discuss how chronic inflammation causes and sustains scar tissue formation (fibrosis) in affected organs and tissues;
- Explain the role of cellular components and cytokines in the pathogenesis of fibrosis and tissue remodeling in the gastrointestinal tract;
- Describe new testing methods to diagnose and quantify fibrosis in the gastrointestinal tract;
- Evaluate medical treatment options for fibrosis of the gastrointestinal tract based on pathogenic mechanisms;
- Identify the principles of endoscopic and surgical treatment of fibrosis of the gastrointestinal tract.
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Directors
Claudio Fiocchi, MD
Department of Gastroenterology and Hepatology
Digestive Disease Institute
Department of Pathobiology
Lerner Research Institute
Cleveland Clinic |
Bret Lashner, MD
Director, Center for Inflammatory Bowel Disease
Department of Gastroenterology and Hepatology
Digestive Disease Institute
Cleveland Clinic |
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Guest Faculty
Silvio Danese, MD, PhD
Head, IBD Center
Division of Gastroenterology
Istituto Clinico Humanitas
Rozzano, Milan, Italy
Rik Derynck, PhD
Professor, Growth and Development, Anatomy
University of California San Francisco
San Francisco, CA
Jonathan Fallowfield, PhD, BSc, BM, MRCP
Academy of Medical Sciences
Health Foundation Clinician Scientist
Honorary Consultant Hepatologist MRC
University of Edinburgh Centre for
Inflammation Research
Queen’s Medical Research Institute
Edinburgh, United Kingdom
Subrata Ghosh, MD
Professor, Department of Medicine
Head, Division of Gastroenterology
University of Calgary
Calgary, Canada
P. Kay Lund, PhD
Professor, Cell and Molecular Physiology
The University of North Carolina
Chapel Hill, NC
Jane E. Onken, MD, MHS
Associate Professor of Medicine
Director, Inflammatory Bowel Disease Clinic
Division of Gastroenterology
Duke University Medical Center
Durham, NC
Massimo Pinzani, MD, PhD
Professor of Medicine
Department of Internal Medicine
University of Florence School of Medicine
Florence, Italy
Donald W. Powell, MD
Director, Clinical Research Center
Institution for Translational Sciences
Director, Division of Gastroenterology & Hepatology
Bassel and Frances Blanton Distinguished
Professor of Internal Medicine
Professor of Neuroscience and Cell Biology
The University of Texas Medical Branch
Galveston, TX |
Miquel Sans, MD, PhD
IBD Unit
Department of Gastroenterology
Institute of Digestive Diseases
Hospital Clinic / IDIBAPS
Barcelona, Spain
Shelia Violette, PhD
Vice President, Research
Stromedix, Inc.
Cambridge, MA
Georg Wick, PhD
Professor, Division for Experimental
Pathology and Immunology
Laboratory of Autoimmunity, Biocenter
Innsbruck Medical University
Innsbruck, Austria
Thomas Wight, PhD
Member and Director, Hope Heart Program
Benaroya Research Institute at Virginia Mason
Seattle, WA
Joseph Willis, MD
Associate Professor, Institute of Pathology
Case Western Reserve University
Cleveland, OH
Thomas Wynn, PhD
Chief, Immunopathogenesis Section
Senior Investigator
National Institutes of Health
Bethesda, MD
Ellen Zimmermann, MD
Associate Professor of Medicine,
Gastroenterology
University of Michigan
Ann Arbor, MI |
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Cleveland Clinic Faculty
Aaron Brzezinski, MD
Department of Gastroenterology and Hepatology
Digestive Disease Institute
Leonard Calabrese, DO
Professor of Medicine
R.J. Fasenmyer Chair of Clinical Immunology
Cleveland Clinic Lerner College of Medicine
of Case Western Reserve University
Vice Chairman, Department of
Rheumatic and Immunologic Diseases
Orthopaedic and Rheumatologic Institute
Carol A. de la Motte, PhD
Department of Pathobiology
Lerner Research Institute
Victor W. Fazio, MD, MS, FRACS, FACS
Physician Director, Institutional Relations
and Development
Emeritus Chairman
Department of Colorectal Surgery
Digestive Disease Institute
Arthur McCullough, MD
Department of Gastroenterology and Hepatology
Digestive Disease Institute
Laura Nagy, PhD
Department of Pathobiology
Lerner Research Institute |
Florian Rieder, MD, PhD
Department of Gastroenterology and Hepatology
Digestive Disease Institute
Takao Sakai, MD, PhD
Department of Biomedical Engineering
Lerner Research Institute
Bo Shen, MD
Department of Gastroenterology and Hepatology
Digestive Disease Institute
Tyler Stevens, MD
Department of Gastroenterology and Hepatology
Digestive Disease Institute
John Vargo, MD, MPH
Department of Gastroenterology and Hepatology
Digestive Disease Institute
Nizar Zein, MD, FACG
Chief, Section of Hepatobiliary Disease
Medical Director, Liver Transplantation
Mikati Foundation Endowed Chair in
Liver Disease
Department of Gastroenterology
and Hepatology
Digestive Disease Institute |
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Agenda
Tuesday, September 28 | Wednesday, September 29
| TUESDAY, SEPTEMBER 28, 2010 |
| 7:00 am |
Registration / Continental Breakfast /
Exhibits |
| 8:00 am |
Welcome - Art McCullough, MD, and
Victor Fazio, MD |
| Session I: |
Inflammation in the Gastrointestinal Tract:
Mechanisms and Therapy
Moderators: Bret Lashner, MD, and
Art McCullough, MD |
| 8:10 am |
Intestinal Inflammation:
Mechanisms, Consequences,
and Outcomes - Claudio Fiocchi, MD |
| 8:30 am |
Immune and Nonimmune
Components of Intestinal
Inflammation - Silvio Danese, MD |
| 8:50 am |
The Immunology of Fibrosis:
Innate and Adaptive Responses - Georg Wick, PhD |
| 9:10 am |
Biological Agents in
Inflammation: Today and
Tomorrow - Leonard Calabrese, DO |
| 9:30 am |
Panel Discussion |
| 9:50 am |
Refreshments / Exhibits |
| Session II: |
Mechanisms of Fibrogenesis
Moderators: Claudio Fiocchi, MD |
| 10:20 am |
Mechanisms of Fibrogenesis:
An Overview - Thomas Wynn, PhD |
| 10:40 am |
The Central Role of TGF Beta
in Fibrosis - Rik Derynck, PhD |
| 11:00 am |
TNF: A Pro-Fibrotic or An
Anti-Fibrotic Agent? - Subrata Ghosh, MD |
| 11:20 am |
The Intestinal Myofibroblast - Don Powell, MD |
| 11:40 am |
Panel Discussion |
| 12:00 pm |
Lunch |
| Session III |
Young Investigators Session
Moderators: Claudio Fiocchi, MD, and
Florian Rieder, MD |
| 1:00 – 2:00 pm |
Young Investigator Presentations
(Each speaker will give a 15-minute presentation) |
| 2:15 pm |
Panel Discussion |
| 2:30 pm |
Refreshments / Exhibits |
| 3:00 – 4:00 pm |
Young Investigator Presentations
(Each speaker will give a 15-minute presentation) |
| 4:00 pm |
Panel Discussion |
| 4:15 pm |
Summary by Senior Experts |
| 4:30 pm |
Adjourn |
| 4:30 pm |
Reception |
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| WEDNESDAY, SEPTEMBER 29, 2010 |
| 7:00 am |
Registration / Continental Breakfast /
Exhibits |
| Session IV |
Mechanisms of Fibrogenesis in the
Gastrointestinal Tract
Moderators: Don Powell, MD, and Kay Lund, PhD |
| 8:00 am |
The Extracellular Matrix:
Active or Passive Player
in Fibrosis? - Thomas Wight, PhD |
| 8:20 am |
Hyaluronan in Mucosal
Immunity and Inflammation - Carol de la Motte, PhD |
| 8:40 am |
Fibrogenesis in Gut
Inflammation: Human and
Animal Models - Kay Lund, PhD |
| 9:00 am |
Mesenchimal Cell Proliferation and Programmed Cell Death: New Target for Intervention - Miquel Sans, MD, PhD |
| 9:20 am |
Panel Discussion |
| 9:40 am |
Refreshments / Exhibits |
| Session V |
Fibrosis in the Gastrointestinal Tract:
Clinical and Therapeutic Aspects
Moderators: Bret Lashner, MD, and
Aaron Brzezinski, MD |
| 10:10 am |
Fibrosis in Crohn’s Disease
and Ulcerative Colitis:
Differences and Similarities - Joseph Willis, MD |
| 10:30 am |
New Imaging Techniques for
Intestinal Fibrosis - Ellen Zimmermann, MD |
| 10:50 am |
Markers for Risk and
Outcomes in Intestinal Fibrosis - Florian Rieder, MD |
| 11:10 am |
Developing a Clinical
Biomarker Strategy in
Fibrotic Disease - Shelia Violette, PhD |
| 11:30 am |
Stem Cell Therapy for Fibrosis - Jane Onken, MD |
| 11:50 am |
Panel Discussion |
| 12:10 pm |
Lunch |
| Session VI |
Liver Fibrosis
Moderators: Art McCullough, MD, and
Nizar Zein, MD |
| 1:10 pm |
Animal Models for the Study of
Liver Fibrosis - Takao Sakai, MD |
| 1:30 pm |
Liver Stellate Cells - Massimo Pinzani, MD |
| 1:50 pm |
Obesity, Diabetes, and
Liver Fibrosis - Laura Nagy, PhD |
| 2:10 pm |
Therapeutic Targets in
Liver Fibrosis - Jonathan Fallowfield, PhD |
| 2:30 pm |
Biological Agents in NAFLD - Arthur McCullough, MD, and
Nizar Zein, MD |
| 2:50 pm |
Panel Discussion |
| 3:10 pm |
Refreshments / Exhibits |
| Session VII |
Fibrosis in the Gastrointestinal Tract:
Special Situations
Moderators: Art McCullough, MD, and
Tyler Stevens, MD |
| 3:40 pm |
Endoscopic Approaches to
Gastrointestinal Strictures - John Vargo, MD |
| 4:00 pm |
Pancreatic Stellate Cells: Target for Treatment of Chronic Pancreatitis - Tyler Stevens, MD |
| 4:20 pm |
Management of IBD Associated
Strictures - Bo Shen, MD |
| 4:40 pm |
Panel Discussion |
| 5:00 pm |
Closing Remarks - Art McCullough, MD, and
Victor Fazio, MB |
| 5:10 pm |
Adjourn |
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Location
InterContinental Hotel and Bank of America Conference Center
9801 Carnegie Ave.
Cleveland, OH 44106
Phone: 216.707.4000 or 877.707.8999
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Hotel Accommodations
A block of rooms has been reserved at the InterContinental Hotel until
September 2, 2010. To make your reservations, contact the Hotel
Reservations Department at 216.707.4100 or 877.707.8999. Please identify
yourself as being with the Cleveland Clinic Digestive Disease Institute
Week, (registration code IX8) for a special rate of $189 single/double
plus tax. The hotel and conference center is located on the campus of the
Cleveland Clinic.
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Parking
Parking is available in the East 100th Street. Visitor’s Parking Garage at
prevailing rates. Valet parking is available at the hotel for an additional charge.
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Ground Transportation
Taxi service is available from Cleveland Hopkins International Airport to the
InterContinental Hotel and Bank of America Conference Center.
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Additional Information
For further information about these courses, contact the Cleveland Clinic
Center for Continuing Education at:
Local: 216.448.0770
Toll Free: 800.238.6750
For questions about registering online, call 216.448.0777 or email CMEregistration@ccf.org.
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Faculty Disclosure
The Cleveland Clinic Foundation Center for Continuing Education has
implemented a policy to comply with the current Accreditation Council for
Continuing Medical Education Standards for Commercial Support requiring
resolution of all faculty conflicts of interest. Faculty declaring a relevant
commercial interest will be identified in the activity syllabus.
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Americans with Disabilities Act
The Cleveland Clinic Foundation Center for Continuing Education fully intends
to comply with the legal requirements of the Americans with Disabilities Act. If
you need assistance, please notify us at least two weeks prior to the activity.
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Accreditation
The Cleveland Clinic Foundation Center for Continuing Education is accredited
by the Accreditation Council for Continuing Medical Education to provide
continuing medical education for physicians.
The Cleveland Clinic Foundation Center for Continuing Education designates
this educational activity for a maximum of 13.75 AMA PRA Category 1
Credits™. Physicians should only claim credit commensurate with the extent
of their participation in the activity.
Participants claiming CME credit from this activity may submit the credit
hours to the American Osteopathic Association Council on Continuing Medical
Education for Category 2 credit.
The Cleveland Clinic (OH–45/10-01-09) is an approved provider of continuing
nursing education by the Ohio Nurses Association (OBN-001-91), an accredited
approver by the American Nurses Credentialing Center’s Commission on
Accreditation. CNE’s pending.
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Registration & Cancellation
Preregistrations are accepted until 4:00 pm ET September 23, 2010.
Please register on-site after this date.
In case of cancellation, a full refund will
be made if canceled by September 20, 2010. After September 20, 2010, a
$50 cancellation fee will be deducted from your refund. Written notification of
your cancellation is required to process your refund.
NO REFUNDS WILL BE
ISSUED AFTER OCTOBER 31, 2010.
For questions about registration, please call 216.448.0777 or email us at cmeregistration@ccf.org.
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Online Registration/Fees
Registration fee includes syllabus, continental breakfasts, lunches, refreshment breaks, and reception for all courses.
TO REGISTER PER DAY CALL 216.448.0777
| CATEGORY |
FULL EVENT
|
PER DAY
|
ONSITE FULL EVENT |
ONSITE PER DAY |
| Physician |
$395.00 |
$200.00 |
$445.00 |
$250.00 |
| Comprecare Affiliate |
$256.75 |
$130.00 |
$306.75 |
$180.00 |
| Cleveland Clinic Alumni |
$237.00 |
$120.00 |
$287.00 |
$170.00 |
| Resident / Fellow |
$220.00 |
$110.00 |
$270.00 |
$160.00 |
| Nurse / Nurse Practitioner / Allied Health Professional |
$220.00 |
$110.00 |
$270.00 |
$160.00 |
| CCHS Physician |
$395.00 |
$200.00 |
$445.00 |
$250.00 |
| CCHS Resident / Fellow |
$175.00 |
$90.00 |
$225.00 |
$140.00 |
| CCHS Nurse / Nurse Practitioner / Allied Health Professional |
$175.00 |
$90.00 |
$225.00 |
$140.00 |
| CCF Physician |
$100.00 |
$50.00 |
$150.00 |
$100.00 |
| CCF Resident / Fellow |
$75.00 |
$40.00 |
$125.00 |
$90.00 |
| CCF Nurse / Nurse Practitioner / Allied Health Professional |
$75.00 |
$40.00 |
$125.00 |
$90.00 |
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