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Course Information

An Invitation from Dr. Charis Eng

Dear Colleagues and Friends,

I am pleased to invite you to attend the Genomic Medicine Institute and Center for Personalized Genetic Healthcare’s virtual 4th Annual International PTEN Symposium: From Patient-Centered Research to Clinical Care. We are planning an engaging day with an emphasis on advances in the diagnosis, management and treatment of patients with PTEN Hamartoma Tumor Syndrome (PHTS). We welcome you to join us via our event livestream.

Pier Paolo Pandolfi, MD, PhD, FRCP, senior scientist at the Renown Institute for Cancer and honorary professor of molecular biology at the University of Turin, will deliver the morning keynote address. Neil Friedman, MBChB, pediatric neurologist and director of quality, outcomes, and innovation at Barrow Neurological Institute at Phoenix Children’s Hospital, will deliver the afternoon keynote address on the neurological spectrum of PHTS. Other topics include hormone use and high-risk patients, gynecological cancer risks, updates on PTEN clinical trials, and autism. Please refer to the enclosed agenda for more details about this year’s speakers and topics.

I am sure you will enjoy this day of education and discussion centered on our common interests in PTEN patient-centered research and clinical care. A highlight of the program is certain to be our Patient Experience Panel, which will provide the opportunity to hear unique patient perspectives on PTEN and family dynamics. We will close the day with remarks from Kristin Anthony, president of the PTEN Hamartoma Tumor Syndrome Foundation; and Claudio Ales, president of PTEN Italia; and myself.


Charis Eng, MD, PhD
Hardis Chair, Genomic Medicine Institute
Director, Center for Personalized Genetic Healthcare
Medical Director, PTEN/Cowden Multidisciplinary Clinic
Cleveland Clinic

Course Overview

This program, presented by Cleveland Clinic’s Genomic Medicine Institute and Center for Personalized Genetic Healthcare, will provide the opportunity to review the latest advances in PTEN Hamartoma Tumor Syndrome (PHTS) and offer state-of-the-art information to healthcare providers treating patients with germline PTEN mutations. Expert Cleveland Clinic and guest faculty will share case-based presentations and research highlighting the advances of genetics and genomics of PHTS and the science of PTEN.

Who Should Attend

We invite practitioners and healthcare professionals seeking to learn the latest developments in PTEN management and research, especially providers in Oncology, Internal Medicine and Subspecialties, Pediatrics, Neurology, Dermatology, Endocrinology, Gastroenterology, Medical Genetics, Genetic Counseling, Nephrology, Urology, Women’s Health and Psychology/Psychiatry. Additionally, trainees and students with an interest in expanding their knowledge of PHTS and the science of PTEN are encouraged to attend. Patients, families and caregivers are also invited to attend to learn about cutting-edge PTEN research as well as clinical surveillance and management guidelines.

By Attending, You Will Be Able To:

  • Describe current PTEN translational and clinical research
  • Apply research information about PHTS to diagnosis, screening, surveillance, guidelines, patient needs, clinical features and coordination of multidisciplinary team care
  • Demonstrate awareness and share education about PHTS, leading to timely diagnosis, appropriate surveillance and improved patient outcomes