| April
1, 2006 - June 30, 2006 |
Silverman
GJ. Therapeutic B cell depletion and regeneration in rheumatoid
arthritis: Emerging Patterns and Paradigms. Arthritis Rheum 2006;54:2356-67.
In this article,
Dr. Gregg Silverman reviews the current literature regarding how
the actions of anti-CD20 treatment on B-cell depletion and reconstitution
may impact the immune system. This is explored by examining factors
that influence depletion, the pattern of B-cell depletion and reconstitution,
and questions regarding how B-cell depleting therapies affect lymphocytes
in tissue. This excellent article clearly and concisely summarizes
these topics in a format that is useful for practicing physicians
who seek to better understand the possible mechanisms of B-cell
directed therapies as well as for scientists working in this field.
Roll
P, Palanchamy A, Kneitz C, Dorner T, Tony HP. Regeneration of B
cell subsets after transient B cell depletion using anti-CD-20 antibodies
in rheumatoid arthritis. Arthritis Rheum 2006; 54:2377-86.
In this study,
Roll and colleagues sought to delineate the regeneration profile
of B-cell subsets in the peripheral blood after anti-CD-20 treatment.
From serial analyses in 27 patients treated with anti-CD-20, a characteristic
pattern of B cell regeneration was seen in which immature B cells
(CD38high, IgD+, CD10+,CD24high) were the first to return followed
by naïve B cells. CD27+ memory B cells had a slow and delayed
repopulation with the level staying significantly reduced for more
than 2 years. This study provides important information on the immunobiologic
changes in B cell depletion and reconstitution that occurs following
anti-CD-20 therapy.
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