Webcast CME

Biologic Therapies VII: Precision Medicine in the Biologic Era


Autoimmune Complications from Cancer Chemotherapy: An Emerging Field

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Release Date:   May 23, 2017
Expiration Date:   May 23, 2019

Estimated Time of Completion:   30 minutes

Description

Biologic Therapies VII: Precision Medicine in the Biologic Era online series brings together world leaders in immune-based therapies and addresses cutting-edge translational immunology and the latest data on biologic therapeutics.

This webcast will review immune checkpoint inhibitors (ICIs) as one type of cancer immunotherapy and will show data that increases survival in a variety of advanced malignancies by blocking negative costimulatory molecules, thus increasing activation of T cells. This presentation will focus on their mechanism, adverse events, and consequences.

Learning Objectives

  1. Review T cell costimulation and how immune checkpoints regulate T cell activation.
  2. Discuss immune checkpoint inhibitors (ICIs) and how they can cause immune related adverse events (IRAE).
  3. Discuss inflammatory arthritis as a model rheumatic IRAE.

Target Audience

The online series is designed for rheumatologists, allergists/immunologists, dermatologists, internal medicine physicians, and associated allied health practitioners, including nurse practitioners, nurses, and physician assistants interested in or using biologic therapeutics for autoimmune and inflammatory disorders.

Accreditation

The Cleveland Clinic Foundation Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The Cleveland Clinic Foundation Center for Continuing Education designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.

Activity Directors and Faculty

Activity Directors

Leonard H. Calabrese, DO
Professor of Medicine
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
R.J. Fasenmyer Chair of Clinical Immunology
Department of Rheumatic and Immunologic Diseases
Orthopaedic and Rheumatologic Institute
Cleveland Clinic
Cleveland, OH

M. Elaine Husni, MD, MPH
Director, Arthritis and Musculoskeletal Treatment Center
Vice Chair, Department of Rheumatic and Immunologic Diseases
Orthopaedic and Rheumatologic Institute
Cleveland Clinic
Cleveland, OH

Faculty

Laura Cappelli, MD, MHS
Instructor of Medicine
Division of Rheumatology
Johns Hopkins School of Medicine
Baltimore, MD

CME Disclaimer

The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.

Disclosures

In accordance with the Standards for Commercial Support issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Foundation Center for Continuing Education requires resolution of all faculty conflicts of interest to ensure CME activities are free of commercial bias.

The following faculty have indicated that they may have a relationship which, in the context of their presentation, could be perceived as a potential conflict of interest:


Leonard H. Calabrese, DO
  AbbVie Pharmaceuticals; Bristol Myers Squibb;
Genentech/ Roche; Janssen
Consulting; Teaching and Speaking
  GlaxoSmithKline; Pfizer, Inc.; UCB Consulting
  Crescendo Teaching and Speaking
M. Elaine Husni, MD, MPH
  AbbVie Pharmaceuticals; Genentech; Janssen Consulting
  Amgen; Bristol-Myers Squibb; Genzyme/Sanofi; Lilly, Regeneron Consulting;
Membership on advisory committee or review panels
  Novartis Pharmaceuticals Consulting; Teaching and Speaking
  Pfizer, Inc. Membership on advisory committee or review panels

The following faculty has indicated that she has no relationship which, in the context of her presentation, could be perceived as a potential conflict of interest:

Laura Cappelli, MD

The Cleveland Clinic Foundation Center for Continuing Education
acknowledges educational grants for partial support of this activity from:

AbbVie, Inc.
Amgen, Inc.
Bristol-Myers Squibb Co.
Celgene Corporation
Crescendo Bioscience, Inc.
Genentech
Janssen Scientific Affairs, LLC
Novartis Pharmaceuticals Corporation
UCB, Inc.

This CME activity was produced by the Cleveland Clinic Foundation Center for Continuing Education
and the R.J. Fasenmyer Center for Clinical Immunology.