Multiple Sclerosis Case-based Online Monograph

1. Recognize the changes in understanding of MS pathology including evidence of active immune surveillance in the spinal fluid and early cortical lesions.
2. Summarize evidence on diagnostic use of MRI using updated guidelines for MS.
3. Critically compare the efficacies, mode of action, pharmacology, and side effect profiles of recently approved disease modifying agents for MS.
4. Describe the clinical role of the newer agents in strategies for treating patients with relapsing MS.
5. Develop a risk mitigation strategy to reduce adverse effects associated with disease modifying therapies.
6. Summarize research on incidence of comorbidities associated with MS and their potential impact on MS.
7. Describe the importance of depression and cognitive impairment in patients with MS and identify strategies to address depression management in these patients.

The educational activity is designed for neurologists, psychiatrists, neurology residents, neuroimmunology fellows, and allied health professionals, including nurse practitioners and physician assistants.

The Cleveland Clinic Foundation Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The Cleveland Clinic Foundation Center for Continuing Education designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.

Activity Director

Alexander D. Rae-Grant, MD
Mellen Center for Multiple Sclerosis Treatment and Research
Cleveland Clinic
Cleveland, OH

Faculty

Alasdair Coles, PhD
Department of Clinical Neurosciences
University of Cambridge
Cambridge, England

Devon Conway, MD, MS
Assistant Professor
Cleveland Clinic Lerner College of Medicine
Staff Neurologist
Mellen Center for Multiple Sclerosis
Neurological Institute
Cleveland Clinic
Cleveland, OH

Carrie M. Hersh, DO, MSc
Cleveland Clinic
Cleveland, OH

Le H. Hua, MD
Eric and Sheila Samson Chair for Multiple Sclerosis Research
Director, Mellen Program for Multiple Sclerosis
Lou Ruvo Center for Brain Health
Cleveland Clinic
Las Vegas, NV

Stephen Jones, MD, PhD
Diagnostic Radiology
Cleveland Clinic
Cleveland, OH

Elias Khawam, MD
Cleveland Clinic
Cleveland, OH

Fred Lublin, MD
Saunders Family Professor of Neurology
Director, Corinne Goldsmith Dickinson Center for Multiple Sclerosis
Mount Sinai Medical Center
New York, NY

Don J. Mahad, MD, PhD
Centre for Clinical Brain Sciences
Anne Rowling Regenerative Neurology Clinic
Centre for Neuroregeneration
The University of Edinburgh
Edinburgh, Scotland

Marisa McGinley, MD
Mellen Center for Multiple Sclerosis Treatment and Research
Cleveland Clinic
Cleveland, OH

Daniel Ontaneda, MD, MSc
Staff Neurologist
Mellen Center for Multiple Sclerosis
Cleveland Clinic
Cleveland, OH

Mary Alissa Willis, MD
Staff Neurologist
Mellen Center for Multiple Sclerosis
Cleveland Clinic
Cleveland, OH

Dean M. Wingerchuk, MD, MSc, FRCP(C)
Mayo Clinic
Phoenix/Scottsdale, AZ

How to Obtain AMA PRA Category 1 Credit™

1. Complete the activity, including any questions or post test.
2. Proceed to complete the CME process and log into your myCME account.
3. Complete the application for credit, including the evaluation.
4. Save your personalized CME certificate.

Note: Credit can only be claimed once for each activity.

The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.