Emerging Treatments in iMIDS

• Describe the process by which “safety signals” emerge.
• Highlight case studies of where this has gone awry.
• Recommend solutions for a forward-looking safety-agenda.
• Examine the mechanism of action of Janus kinase (JAK) inhibitors in modulating immune responses, and identify the potential toxicities and adverse effects, particularly infection risks, to ensure the optimal administration of JAK inhibitors in patients.
• Critically evaluate emerging therapeutic strategies for difficult-to-treat psoriatic arthritis (PsA), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and inflammatory myopathies, and propose innovative approaches to optimize patient outcomes based on current advancements.

The online series is directed towards rheumatologists, allergists/immunologists, dermatologists, internal medicine physicians, nurse practitioners, nurses, and physician assistants interested in or using biologic therapeutics for autoimmune and autoinflammatory disorders.

In support of improving patient care, Cleveland Clinic Center for Continuing Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians / American Medical Association (AMA)
Cleveland Clinic Center for Continuing Education designates this internet enduring activity for a maximum of 2.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.

Nurses / American Nurses Credentialing Center (ANCC)
Cleveland Clinic Center for Continuing Education designates this internet enduring activity for a maximum of 2.75 ANCC contact hours.

Physician Assistants / American Academy of PAs (AAPA)
Cleveland Clinic Center for Continuing Education has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 2.75 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.

Certificate of Participation
A certificate of participation will be provided to other health care professionals for requesting credits in accordance with their professional boards and/or associations.

Activity Director

Leonard H. Calabrese, DO
R.J. Fasenmyer Chair of Clinical Immunology
Department of Rheumatic & Immunologic Diseases
Medical Specialty Institute
Cleveland Clinic
Cleveland, OH

Cassandra Calabrese, DO
Department of Rheumatic & Immunologic Diseases
Medical Specialty Institute
Cleveland Clinic
Cleveland, OH

M. Elaine Husni, MD, MPH
Director, Arthritis and Musculoskeletal Treatment Center
Vice Chair, Rheumatology
Department of Rheumatic & Immunologic Diseases
Medical Specialty Institute
Cleveland Clinic
Cleveland, OH

Additional Planners

Debra Kangisser, PA-C
Elizabeth (Betsy) Kirchner, DNP

Faculty

Rohit Aggarwal, MD, MS
Medical Director, Arthritis and Autoimmunity Center
Professor of Medicine
Co-director, UPMC Myositis Center
Division of Rheumatology and Clinical Immunology
University of Pittsburgh
Pittsburgh, PA

Jack Cush, MD
Executive Editor, RheumNow.com

Michelle Petri, MD, MPH
Professor of Medicine
Division of Rheumatology
Johns Hopkins University School of Medicine
Baltimore, MD

Michael Putman, MD, MSci
Assistant Professor of Medicine
Medical Director, Vasculitis Program
Medical College of Wisconsin
Milwaukee, WI

Christopher Ritchlin, MD, MPH
Director, Clinical Immunology Research Unit
University of Rochester Medicine
Rochester, NY

The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.