Webcast CME

Special Series on CAR-T Cell and Advanced Immunotherapeutics for Autoimmune Diseases

View Online Exhibit Hall  

Release date: April 25, 2025
Expiration date: April 24, 2026

Estimated Time of Completion: 2 hours

Session Agenda

Introduction
Leonard Calabrese, DO

CAR-T Cells in Autoimmune Diseases
Georg Schett, MD

Advanced Noncellular Immunotherapeutics
Maximilian F. Konig, MD

Clinical Outcomes of CAR-T Cell Therapy
Emily Littlejohn, DO

Roundtable Discussion
Leonard Calabrese, DO, M. Elaine Husni, MD, MPH, Maximilian F. Konig, MD, Emily Littlejohn, DO, Georg Schett, MD

Description

This education is designed to increase the confidence of frontline clinicians in their understanding of the evolving technologies and clinical aspects of cellular therapies as well as inform them of how to access clinical trials for such therapies for potentially eligible patients. At the same time a growing number of patients are expressing interest in this new field and frontline clinicians need to be confident in their ability to counsel such patients.

The Basic and Clinical Immunology for the Busy Clinician live and virtual series of meetings has for over a decade been dedicated to translating the many advances in basic and clinical immunology for busy clinicians who lack ready access to ongoing immunologic education. The field of cellular therapy is now at the pinnacle of immunologic interest and thus we are proposing a new dedicated forum to meet the educational needs of busy clinicians to increase their declarative and procedural knowledge regarding cellular therapies including learning how to access cellular therapy trials for their patients. The rapid advancements in CAR-T cell therapy and other cellular therapies for autoimmune diseases have created a pressing need for clinicians to stay informed and confident in this evolving field. The complexity of these therapies, combined with their potential to revolutionize treatment protocols, demands a focused educational effort. This Town Hall will provide clinicians with the knowledge and tools necessary to effectively guide their patients through these innovative treatment options and emerging clinical trials.

Learning Objectives

  • Describe the history and immunologic underpinnings of CAR-T cell and other cellular and advanced therapies and the data supporting their potential to achieve immunologic remission across multiple autoimmune disease states.
  • Critically appraise the data on both efficacy and toxicity of cellular therapy from the experience in cancer and autoimmunity.
  • Describe the practical aspects of cellular therapy including the patient journey of having received cellular therapy and to increase awareness of current CAR-T cell and cellular therapy protocols and how to access them.

Target Audience

The online series is directed to physicians, physician assistants, nurse practitioners, and nurses with an interest in rheumatology, immunology, neurology, nephrology, and dermatology.

Accreditation

In support of improving patient care, this activity has been planned and implemented by Cleveland Clinic Center for Continuing Education. Cleveland Clinic Center for Continuing Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physicians / American Medical Association (AMA)
Cleveland Clinic Center for Continuing Education designates this internet enduring activity for a maximum of 2.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.

Nurses / American Nurses Credentialing Center (ANCC)
Cleveland Clinic Center for Continuing Education designates this internet enduring activity for a maximum of 2.0 ANCC contact hours.

Physician Assistants / American Academy of PAs (AAPA)
Cleveland Clinic Center for Continuing Education has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 2.0 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.

Certificate of Participation

A certificate of participation will be provided to other health care professionals for requesting credits in accordance with their professional boards and/or associations.

Activity Director and Faculty

Activity Directors

Cassandra Calabrese, DO
Department of Rheumatic and Immunologic Diseases
Medical Specialty Institute
Cleveland Clinic
Cleveland, OH

Leonard H. Calabrese, DO
Professor of Medicine
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
R.J. Fasenmyer Chair of Clinical Immunology
Department of Rheumatic and Immunologic Diseases
Medical Specialty Institute
Cleveland Clinic
Cleveland, OH

M. Elaine Husni, MD, MPH
Director, Arthritis and Musculoskeletal Treatment Center
Vice Chair of Rheumatology
Department of Rheumatic and Immunologic Diseases
Medical Specialty Institute
Cleveland Clinic
Cleveland, OH

Emily Littlejohn, DO
Department of Rheumatic & Immunologic Diseases
Medical Specialty Institute
Cleveland Clinic
Cleveland, OH

Additional Planners

Debra Kangisser, PA-C
Clinical Affairs, PA Services
Cleveland Clinic
Cleveland, OH

Elizabeth (Betsy) Kirchner, DNP
Department of Rheumatic & Immunologic Diseases
Medical Specialty Institute
Cleveland Clinic
Cleveland, OH

Independent Peer Reviewer

Elizabeth File, MD

Faculty

Maximilian F. Konig, MD
Assistant Professor of Medicine
Director, Cellular Therapy Program (Autoimmunity)
Division of Rheumatology, Department of Medicine
The Johns Hopkins University School of Medicine
Baltimore, MD

Prof. Dr. Georg Schett
Head of Department of Medicine 3 – Rheumatology and Immunology
Uniklinikum Erlangen

Disclosures

In accordance with the Standards for Integrity and Independence issued by the Accreditation Council for Continuing Medical Education (ACCME), Cleveland Clinic Center for Continuing Education mitigates all relevant conflicts of interest to ensure CME activities are free of commercial bias. All relevant financial relationships have been mitigated.

The following faculty have indicated that they may have a relationship, which in the context of their presentation(s), could be perceived as a potential conflict of interest:

Cassandra Calabrese, DO
Astra Zeneca, Sanofi-Regeneron Consulting
Teaching and Speaking
Lilly, Pfizer Consulting
Leonard Calabrese, DO
Astra Zeneca Teaching and Speaking
Abbvie Pharmaceuticals, GSK, Novartis, Sanofi Aventis Consulting
Genentech/Roche Consulting
Advisor or review panel participant
Teaching and Speaking
Janssen, UCB Consulting
Teaching and Speaking
M. Elaine Husni, MD
Abbvie Pharmaceuticals, Amgen, Bristol-Myers Squibb Co., Janssen, Lilly, Regeneron Consulting
Advisor or review panel participant
Novartis Pharmaceuticals Consulting
Advisor or review panel participant
Teaching and Speaking
Pfizer, Inc. Advisor or review panel participant
UCB, Inc. Consulting
National Psoriasis Foundation Other activities from which remuneration is received or expected
Research
Elizabeth Kirchner, DNP
Janssen Pharmaceuticals, Inc., Lilly, Pfizer Consulting
RhAPP Teaching and Speaking
Maximilian Konig, MD
Allogene, Atara Biotherapeutics, ArgenX, Revel Pharmaceuticals, Sanofi Consulting
BMS Teaching and Speaking
Emily Littlejohn, DO
Synthekine Consulting
Aurinia Pharmaceuticals Teaching and Speaking

All other individuals have indicated no relationship which, in the context of their involvement, could be perceived as a potential conflict of interest.


Acknowledgment

The Cleveland Clinic Center for Continuing Education acknowledges educational grants for partial support of this activity from:
Fate Therapeutics Inc.
Mylan Inc., a Viatris Company

Thank you to our Platinum Level exhibitors:
Abbvie
Bristol Myers Squibb
Sanofi

This CME activity was produced by the Cleveland Clinic Foundation Center for Continuing Education and Cleveland Clinic’s R.J Fasenmyer Center for Clinical Immunology.