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Basic and Clinical Immunology

Antigen Presentation, T Cell Activation and

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Release Date:   March 15, 2017
Expiration Date:   March 15, 2019

Estimated Time of Completion:   45 minutes


Clinical immunology is rapidly evolving, and it is challenging for the practicing clinician to keep abreast of the advances. The Basic and Clinical Immunology Webcast Series provides clinicians with a review of basic and clinical immunology. The webcast series is composed of A-B-C teaching with an emphasis on biologic principles and implications.

This webcast reviews antigen recognition and T cell ontogeny.

Learning Objectives

  1. Describe the ontogeny of T cell development and antigen presentation.
  2. Define T cell receptor complex at the immunologic synapse.
  3. Summarize the potential roles of T cell activation and costimulation (CD28, CTLA, etc) in health and disease.
  4. Critically review the pharmacology of TGN1412, its mechanism of action, and the controversy regarding its clinical trial results.
  5. Summarize the role of PD1 and CTLA4 in cancer development.

Target Audience

This activity is directed to rheumatologists, dermatologists, allergists, internal medicine physicians, pulmonologists, nurse practitioners, physician assistants, and other health care professionals caring for patients with immunologic diseases.


The Cleveland Clinic Foundation Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The Cleveland Clinic Foundation Center for Continuing Education designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.

Activity Director and Faculty

Leonard Calabrese, DO
Professor of Medicine
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
R.J. Fasenmyer Chair of Clinical Immunology
Orthopaedic and Rheumatologic Institute
Cleveland Clinic
Cleveland, OH

CME Disclaimer

The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.


In accordance with the Standards for Commercial Support issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Foundation Center for Continuing Education requires resolution of all faculty conflicts of interest to ensure CME activities are free of commercial bias.

The following faculty has indicated that he may have a relationship which, in the context of his presentation, could be perceived as a potential conflict of interest:

Leonard Calabrese, DO
  Regeneron Consulting

The Cleveland Clinic Foundation Center for Continuing Education
acknowledges educational grants for partial support of this activity from:

AbbVie, Inc.
Bristol-Myers Squibb
Celgene Corporation
Mallinckrodt LLC

This CME activity was produced by the Cleveland Clinic Foundation Center for Continuing Education
and the R.J. Fasenmyer Center for Clinical Immunology.