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Basic and Clinical Immunology

B Cell Biology and T Follicular Helper Cells –
The Fundamentals

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Release Date:   March 15, 2017
Expiration Date:   March 15, 2019

Estimated Time of Completion:   45 minutes


Clinical immunology is rapidly evolving, and it is challenging for the practicing clinician to keep abreast of the advances. The Basic and Clinical Immunology Webcast Series provides clinicians with a review of basic and clinical immunology. The webcast series is composed of A-B-C teaching with an emphasis on biologic principles and implications.

This webcast reviews antigen-specific B cells and T cells.

Learning Objectives

  1. Identify how antigenic selection molds the B-cell repertoire.
  2. Evaluate how germinal center (GC) reactions coordinate interactions of antigen-specific B cells and T cells for effective antibody responses.
  3. Discuss how T cells guide germinal center reactions, while mechanistic breaches can result in autoimmune disease.
  4. Discuss possible roles of ectopic lymphoid tissue and GCs in autoimmune inflammatory diseases.

Target Audience

These activities are directed to rheumatologists, dermatologists, allergists, internal medicine physicians, pulmonologists, nurse practitioners, physician assistants, and other health care professionals caring for patients with immunologic diseases.


The Cleveland Clinic Foundation Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The Cleveland Clinic Foundation Center for Continuing Education designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.

Activity Director and Faculty

Activity Director

Leonard Calabrese, DO
Professor of Medicine
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
R.J. Fasenmyer Chair of Clinical Immunology
Orthopaedic and Rheumatologic Institute
Cleveland Clinic
Cleveland, OH


Gregg J. Silverman, MD
Associate Director, Division of Rheumatology
Professor of Medicine and Pathology
NYU School of Medicine
New York, NY

CME Disclaimer

The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.


In accordance with the Standards for Commercial Support issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Foundation Center for Continuing Education requires resolution of all faculty conflicts of interest to ensure CME activities are free of commercial bias.

The following faculty have indicated that they may have a relationship which, in the context of their presentation, could be perceived as a potential conflict of interest:

Leonard Calabrese, DO
  Regeneron Consulting
Gregg J. Silverman, MD
  Genentech Consulting
  Bristol-Myers Squibb Co.; Celgene Corporation;
Membership on advisory committee or review panels

The Cleveland Clinic Foundation Center for Continuing Education
acknowledges educational grants for partial support of this activity from:

AbbVie, Inc.
Bristol-Myers Squibb
Celgene Corporation
Mallinckrodt LLC

This CME activity was produced by the Cleveland Clinic Foundation Center for Continuing Education
and the R.J. Fasenmyer Center for Clinical Immunology.