Webcast CME

 

 

 

 

A Brave New World: The Clinical Management of Bone
Marrow Failure and Myeloid Malignancy in a Time of Personalized Therapy



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Release Date:   January 8, 2018
Expiration Date:   January 8, 2020

Estimated Time of Completion:  3 hours 30 minutes

Description

Brave New World: The Clinical Management of Bone Marrow Failure and Myeloid Malignancy in a Time of Personalized Therapy webcast provides an in-depth and up-todate review of research related to the biology, prognosis, natural history, and therapeutic management of patients with aplastic anemia, paroxysmal nocturnal hemoglobinuria (PNH), myelodysplastic syndromes (MDS), and acute myeloid leukemia (AML).

Learning Objectives

  1. Define the clinical implications of aberrant somatic and germline mutations in normal bone marrow, ICUS (idiopathic cytopenia of undetermined significance), CHIP (clonal hematopoiesis of indeterminate potential), myelodysplastic syndromes (MDS), and other myeloid neoplasms.
  2. Describe the genomic mutations in MPNs and their impact on pathogenesis and treatment options.
  3. Identify the role of targeted therapies in myeloid malignancies.
  4. Describe the impact of checkpoint inhibitors for the treatment of MDS/AML.
  5. Describe the treatment options for aplastic anemia and paroxysmal nocturnal hemoglobinuria (PNH).
  6. Identify the risks and benefits of bone marrow transplant in therapy-related myeloid malignancies.

Target Audience

This educational activity is designed for an international audience including medical oncologists/hematologists, clinical and translational researchers, and other physicians and allied health care professionals treating patients with MDS and other bone marrow failure diseases. In addition, members of patient advocacy groups will benefit from this program.

Accreditation

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The Cleveland Clinic Foundation Center for Continuing Education and Aplastic Anemia & MDS International Foundation. The Cleveland Clinic Foundation Center for Continuing Education is accredited by the ACCME to provide continuing medical education for physicians.

The Cleveland Clinic Foundation Center for Continuing Education designates this enduring material for a maximum of  3.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.

Activity Director and Faculty

Activity Director

Hetty Carraway, MD, MBA
Associate Professor of Medicine
Cleveland Clinic Lerner College of Medicine at Case Western Reserve University
Department of Hematology and Oncology
Taussig Cancer Institute
Cleveland Clinic
Cleveland, OH

Sudipto Mukherjee, MD, PhD, MPH
Associate Professor of Medicine
Cleveland Clinic Lerner College of Medicine at Case Western Reserve University
Department of Hematology and Oncology
Taussig Cancer Institute
Cleveland Clinic
Cleveland, OH

Faculty

Corey Cutler, MD, MPH, FRCPC
Associate Professor of Medicine
Harvard Medical School
Dana-Farber Cancer Institute
Boston, MA

Guillermo Garcia-Manero, MD
Professor
Chief, Section of Myelodysplastic Syndromes
Deputy Chair, Translational Research, Department of Leukemia
Division of Cancer Medicine
The University of Texas MD Anderson Cancer Center
Houston, TX

Mark Levis, MD, PhD
Director, Adult Leukemia Service
Co-Director, Division of Hematologic Malignancies
Professor of Oncology, Medicine, and Pharmacology Sidney Kimmel
Comprehensive Cancer Center at Johns Hopkins
Johns Hopkins University School of Medicine
Baltimore, MD

Laura C. Michaelis, MD
Associate Professor of Medicine
Associate Vice Chair Division of Hematology and Oncology
Medical College of Wisconsin
Milwaukee, WI

Valeria Santini, MD
Associate Professor of Hematology
University of Florence Medical School
Florence, Italy

Gerard Socie, MD, PhD
Head, Graft-Hematology Department
St-Louis Hospital
Paris, France

CME Disclaimer

The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.

Disclosures

In accordance with the Standards for Commercial Support issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Foundation Center for Continuing Education requires resolution of all faculty conflicts of interest to ensure CME activities are free of commercial bias.

The following faculty have indicated that they may have a relationship which, in the context of their presentation, could be perceived as a potential conflict of interest:


Mark Levis, MD, PhD
  Daiichi Sankyo, Inc.; Novartis; Astellas Pharma US, Inc. Consulting
 
Laura C. Michaelis, MD
  Novartis Oncology Membership on advisory committee or review panels
  Celgene Corporation Teaching and Speaking
  Pfizer, Inc. Ownership interest (stock, stock options)
 
Valeria Santini, MD
  Abbvie Pharmaceuticals; Astex Pharmaceuticals; Amgen; Janssen Membership on advisory committee or review panels
  Novartis Teaching and Speaking
  Celgene Corporation; Janssen Membership on advisory committee or review panels
Teaching and Speaking
 
Gerad Socie, MD, PhD
  Alexion Consulting

The following faculty have indicated they have no relationship which, in the context of their presentation, could be perceived as a potential conflict of interest:

Hetty Carraway, MD, MBA
Corey Culter, MD, MPH
Guillermo Garcia-Manero, MD
Sudipto Mukherjee, MD, PhD, MPH

Grantor Acknowledgement – live activity

The Cleveland Clinic Foundation Center for Continuing Education
and the Aplastic Anemia & MDS International Foundation
acknowledges educational grants for partial support of live activity from:


Achillion Pharmaceuticals
Celgene Corporation
Geron Corporation
Incyte Corporation
Jazz Pharmaceuticals
Karyopharm Therapeutics
Onconova Therapeutics, Inc.
Takeda Oncology


Grantor Acknowledgement – enduring activity

The Cleveland Clinic Foundation Center for Continuing Education
and the Aplastic Anemia & MDS International Foundation
acknowledges educational grant for partial support of enduring activity from:


Alexion Pharmaceutical
Achillion Pharmaceuticals
Celgene Corporation
Geron Corporation
Incyte Corporation
Jazz Pharmaceuticals
Onconova Therapeutics, Inc.
Takeda Oncology


This CME activity was produced by the Cleveland Clinic Foundation Center for Continuing Education,
Cleveland Clinic’ Taussig Cancer Institute and Aplastic Anemia & MDS International Foundation.