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  1. Complete the Activity.
  2. Take the CME posttest (each question must be answered correctly).
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Technical Requirements

Pitfalls in the Diagnosis of Multiple Sclerosis

Gradually Progressive Myelopathy

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Release Date:   December 7, 2018
Expiration Date:   December 7, 2020

Estimated Time of Completion:   1 hour


The signs and symptoms associated with multiple sclerosis, the varied aspects of disease progression, lack of specific biomarkers, and difficult-to-interpret imaging results often lead to diagnostic errors, both misdiagnosis and underdiagnosis. With MS, these errors can lead to unnecessary and potentially harmful risks to patients from treatment strategies that are based on incorrect diagnoses. Pitfalls in the Diagnosis of Multiple Sclerosis Case-Based Series will discuss the criteria for diagnosis and review of guidelines to improve diagnosis rates ultimately, improving patient care.

This case will review progressive myelopathy.

Learning Objectives

  1. Identify clinical symptoms that suggest myelopathy.
  2. Describe appropriate evaluation for patients with gradually progressive myelopathy.
  3. Describe the differences between spinal cord imaging in multiple sclerosis versus neuromyelitis optica spectrum disorder.

Target Audience

The educational activity is intended for neurologists, neurology residents, neuroimmunology fellows, and allied health professionals, including nurse practitioners and physician assistants.


The Cleveland Clinic Foundation Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The Cleveland Clinic Foundation Center for Continuing Education designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.

Activity Director and Faculty

Alexander D. Rae-Grant, MD
Mellen Center for Multiple Sclerosis Treatment and Research
Cleveland Clinic
Cleveland, OH

CME Disclaimer

The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.


In accordance with the Standards for Commercial Support issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Foundation Center for Continuing Education requires resolution of all faculty conflicts of interest to ensure CME activities are free of commercial bias.

The following faculty has indicated that he has no relationship which, in the context of his presentation, could be perceived as a potential conflict of interest:

Alexander D. Rae-Grant, MD

All other planners, CME staff, and content reviewers, have no relevant financial relationships to disclose

The Cleveland Clinic Foundation Center for Continuing Education
acknowledges educational grants for partial support of this activity from:

Abbvie, Inc.
Genzyme Corporation

This CME activity was produced by Cleveland Clinic
Center for Continuing Education and
Cleveland Clinic's Mellen Center for Neurology Treatment and Research.