Free Online CME

Disease Management Clinical Decisions

Menopause and Hormone Therapy

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Release date: March 7, 2024
Expiration date: March 6, 2027

Estimated Time of Completion: 1 hour


Each lesson in the Disease Management Clinical Decisions series provides a brief, case-based review of management strategies related to the topic. Questions and multiple-choice answers about the case presented include the rationale for the correct answer. Throughout this case-based lesson, you may proceed to the next question once you answer the question correctly.

Learning Objectives

After completing this case the reader should be able to:

  • Perform a postmenopausal risk assessment that includes vasomotor symptoms, symptoms of genitourinary syndrome of menopause, and osteoporosis in estrogen-deficient postmenopausal women.
  • Appropriately select hormone therapy, particularly estrogen-alone therapy, for postmenopausal women without a uterus.
  • Counsel postmenopausal women regarding the risks and benefits of, and alternatives to, hormone therapy.
  • Summarize changes in the updated North American Menopause Society guidelines on menopause, especially regarding hormone therapy.
  • Describe the effectiveness of hormone therapy for vasomotor symptoms and symptoms of the genitourinary syndrome of menopause, as well as for bone loss and fracture prevention.

Target Audience

Directed to primary care physicians including family practitioners and internists.


In support of improving patient care, Cleveland Clinic Center for Continuing Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

American Medical Association (AMA)
Cleveland Clinic Center for Continuing Education designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association for Category 2 credit.

ABIM MOC:  Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0  Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
Your credit will be reported to the ABIM within 30 days of claiming credit. 

Activity Director and Faculty

Activity Director

Anthony Fernandez, MD, PhD
Director, Medical and Inpatient Dermatology
W.D. Steck Chair of Clinical Dermatology
Medical Co-Director, Center for Continuing Education
Cleveland Clinic
Cleveland, OH

Steven Kawczak, PhD, CHCP, FACEHP
Assistant Professor of Medicine, Cleveland Clinic Lerner College of Medicine of CWRU
Co-Director, Center for Continuing Education
Staff, Center for Educational Resources
Education Institute
Cleveland Clinic
Cleveland, OH


Holly L. Thacker, MD, FACP, MSCP, CCD
Center for Specialized Women's Health
Cleveland Clinic
Cleveland, OH

CME Disclaimer

The information in this educational activity is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition. The viewpoints expressed in this CME activity are those of the authors/faculty. They do not represent an endorsement by The Cleveland Clinic Foundation. In no event will The Cleveland Clinic Foundation be liable for any decision made or action taken in reliance upon the information provided through this CME activity.


In accordance with the Standards for Integrity and Independence issued by the Accreditation Council for Continuing Medical Education (ACCME), The Cleveland Clinic Center for Continuing Education mitigates all relevant conflicts of interest to ensure CME activities are free of commercial bias.

The following faculty has indicated he has no relationship which, in the context of his presentation(s), could be perceived as a potential conflict of interest:

Anthony Fernandez, MD, PhD

Bristol-Myers Squibb Co., UCB, Inc.


Pfizer, Inc.

Research / Independent Contractor

Mallinckrodt Inc., Novartis

Research / Independent Contractor
Teaching and Speaking

Abbvie Pharmaceuticals

Research / Independent Contractor
Advisor or review panel participant
Teaching and Speaking

Kyowa Kirin

Teaching and Speaking

Holly Thacker, MD
Abbvie Pharmaceuticals, Astellas Pharma US, Inc. Consulting
Scynexis, Inc Teaching and Speaking

The following faculty have indicated they have no relationship which, in the context of their presentation(s), could be perceived as a potential conflict of interest:

Steven Kawczak, PhD


This CME activity was produced by The Cleveland Clinic Center for Continuing Education.